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Am J Physiol Heart Circ Physiol 292: H408-H414, 2007. First published September 22, 2006; doi:10.1152/ajpheart.00881.2006 Free Article
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Differential responsiveness of RVLM sympathetic premotor neurons to hypoxia in rabbits

Tadachika Koganezawa and Naohito Terui

Department of Physiology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

Submitted 15 August 2006 ; accepted in final form 17 September 2006

To determine whether differential sympathetic nerve responses to hypoxia are explained by opposing effects of hypoxia upon sympathetic premotor neurons in the rostral ventrolateral medulla (RVLM), the cardiac sympathetic nerve and the renal sympathetic nerve were recorded in anesthetized and vagotomized rabbits. Renal sympathetic nerve was activated by the injection of sodium cyanide solution close to the bifurcation of the common carotid artery and/or by inhalation of hypoxic gas (3% oxygen-97% nitrogen). On the other hand, cardiac sympathetic nerve was inhibited by these stimuli. Barosensitive (inhibited by the stimulation of baroreceptor afferents) reticulospinal (antidromically activated by the stimulation of the spinal cord) neurons in the RVLM were divided into three groups according to their responses to hypoxic stimulation: neurons (Type I, n = 25), the activity of which was inhibited by the injection of sodium cyanide solution close to the bifurcation of the common carotid artery and/or by inhalation of hypoxic gas, neurons (Type II, n = 99), the activity of which was facilitated by the same stimulation, and neurons (Type III, n = 11), the activity of which was not changed. These data indicated that the differential responses of cardiac and renal sympathetic nerves might be due to opposing effects of hypoxia on individual RVLM neurons.

rostral ventrolateral medulla; cardiac sympathetic nerve; renal sympathetic nerve; chemoreceptor; regional different response


Address for reprint requests and other correspondence: N. Terui, Dept. of Physiology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, Univ. of Tsukuba, 1-1-1 Tennodai, Tsukuba Ibaraki 305-8575, Japan (e-mail: terui{at}md.tsukuba.ac.jp)




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