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Am J Physiol Heart Circ Physiol 292: H510-H515, 2007. First published September 15, 2006; doi:10.1152/ajpheart.00748.2006
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Effects of residential exercise training on heart rate recovery in coronary artery patients

Jacopo M. Legramante, Ferdinando Iellamo, Michele Massaro, Sergio Sacco, and Alberto Galante

Dipartimento di Medicina Interna, Università di Roma "Tor Vergata," Rome, Italy; and S. Raffaele Hospital, Velletri, Italy

Submitted 12 July 2006 ; accepted in final form 25 August 2006

The aims of the present study are twofold: 1) to investigate whether heart rate recovery (HRR) after a cycle ergometry test is affected by exercise training and 2) to test the ability of HRR to replicate the baroreflex sensitivity (BRS) changes that occur in response to an exercise training program in coronary artery patients. We randomized 82 coronary artery patients undergoing a residential cardiac rehabilitation program to an exercise training group (TR; n = 43) and an untrained group (UTR; n = 39). All of the patients underwent an exercise test before and after the rehabilitation program. HRR was recorded at the end of the 1st and 2nd min after exercise. BRS was determined at rest before and after treatment. HRR after the 2nd min was significantly improved in TR patients (–21.4 ± 0.9 beats/min) compared with UTR patients (–17.8 ± 1.2 beats/min) at the end of the training program. Improvement in HRR paralleled that in BRS in TR patients (from 3.2 ± 0.3 to 5.3 ± 0.8 ms/mmHg; P < 0.001), whereas no significant change was evident in UTR patients (from 3.5 ± 0 to 4.0 ± 0.4 ms/mmHg; P = 0.230). Our data show that HRR in the 2nd min after the cessation of a cycle ergometer exercise test increased in coronary artery patients after an exercise training period. This result confirms the positive effect induced by exercise training on HRR and extends the conclusions of previous studies to different modalities of exercise (i.e., cycle ergometer). HRR might provide an additional simple marker of the effectiveness of physical training programs in cardiac patients.

coronary artery disease; physical training; heart rate response to exercise



Address for reprint requests and other correspondence: J. M. Legramante, Dipartimento Medicina Interna, Università di Roma "Tor Vergata," Via Montpellier 1, 00133 Roma, Italy (e-mail: legramante{at}med.uniroma2.it)




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Am. J. Physiol. Heart Circ. Physiol.Home page
K. S. Heffernan, C. A. Fahs, K. K. Shinsako, S. Y. Jae, and B. Fernhall
Heart rate recovery and heart rate complexity following resistance exercise training and detraining in young men
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3180 - H3186.
[Abstract] [Full Text] [PDF]




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