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Am J Physiol Heart Circ Physiol 292: H800-H807, 2007. First published September 8, 2006; doi:10.1152/ajpheart.00443.2006
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Arterial pressure transfer characteristics: effects of travel time

¹BMEYE; ²Department of Physiology, Academic Medical Center, University of Amsterdam; ³Department of Medical Physics, Academic Medical Center, University of Amsterdam; and ⁴Department of Physiology, Institute for Cardiovascular Research-Vrije University, Vrije University Medical Center, Amsterdam, The Netherlands; and ⁵Department of Internal Medicine, St. Antonius Ziekenhuis, Nieuwegein, The Netherlands; and ⁶Laboratory of Hemodyn and Cardiovasc Techn, Swiss Federal Institute of Technology, Lausanne, Switzerland

Submitted 3 May 2006 ; accepted in final form 5 September 2006

We investigated the quantitative contribution of all local conduit arterial, blood, and distal load properties to the pressure transfer function from brachial artery to aorta. The model was based on anatomical data, Young's modulus, wall viscosity, blood viscosity, and blood density. A three-element windkessel represented the distal arterial tree. Sensitivity analysis was performed in terms of frequency and magnitude of the peak of the transfer function and in terms of systolic, diastolic, and pulse pressure in the aorta. The root mean square error (RMSE) described the accuracy in wave-shape prediction. The percent change of these variables for a 25% alteration of each of the model parameters was calculated. Vessel length and diameter are found to be the most important parameters determining pressure transfer. Systolic and diastolic pressure changed <3% and RMSE <1.8 mmHg for a 25% change in vessel length and diameter. To investigate how arterial tapering influences the pressure transfer, a single uniform lossless tube was modeled. This simplification introduced only small errors in systolic and diastolic pressures (1% and 0%, respectively), and wave shape was less well described (RMSE, 2.1 mmHg). Local (arm) vasodilation affects the transfer function little, because it has limited effect on the reflection coefficient. Since vessel length and diameter translate into travel time, this parameter can describe the transfer accurately. We suggest that with a, preferably, noninvasively measured travel time, an accurate individualized description of pressure transfer can be obtained.

blood pressure; transfer function; personalization; brachial artery; aorta

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