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Cardiovascular-Renal Mechanisms in Health and Disease

17-Estradiol deficiency reduces potassium excretion in an angiotensin type 1 receptor-dependent manner

Center for the Study of Sex Differences in Health, Aging, and Disease; Georgetown University; Washington, District of Columbia

Submitted 31 August 2006 ; accepted in final form 18 April 2007

This study examined the effects of ovariectomy (OVX) and 17-estradiol (E₂) replacement (OVX + E₂) on renal function in Sprague-Dawley rats. OVX caused a 40% decrease in the fractional excretion of potassium (FE_K⁺) that was prevented by E₂ replacement [Sham, 24.2 ± 2.9%; OVX, 14.5 ± 2.1% (P < 0.05 vs. OVX + E₂); and OVX + E₂, 26.2 ± 2.7%; n = 7–11] and that corresponded to significant increases in plasma potassium [(in mmol/l): Sham, 3.15 ± 0.087; OVX, 3.42 ± 0.048 (P < 0.05 vs. OVX + E₂); and OVX + E₂, 3.19 ± 0.11; n = 7–11]. No effects of OVX were detected on plasma levels of sodium and aldosterone. Angiotensin II type 1 receptor (AT₁R) densities in ovariectomized rats were 1.4-fold and 1.3-fold higher in glomerular [maximum binding capacity (B_max; in fmol/mg protein): Sham, 482 ± 21; OVX, 666 ± 20 (P < 0.05 vs. OVX + E₂); and OVX + E₂, 504 ± 26; n = 7–11] and proximal tubular [B_max (in fmol/mg protein): Sham, 721 ± 16; OVX, 741 ± 24 (P < 0.05 vs. OVX + E₂); and OVX + E₂, 569 ± 23; n = 7–11] membranes compared with E₂ replete animals, respectively. Both the angiotensin-converting enzyme inhibitor captopril and the AT₁R antagonist losartan prevented the OVX-induced decrease in the FE_K⁺ and the increase in renal AT₁R densities, suggesting that E₂ deficiency reduces potassium excretion in an ANG II/AT₁R-dependent manner. These findings may have implications for renal function in postmenopausal women as well as contribute to the reasons underlying the age-induced increase in susceptibility to hypertension-associated disease in women.

estrogen; glomeruli; renal cortex; mean arterial pressure

This article has been cited by other articles:

				H. Ji, S. Menini, W. Zheng, C. Pesce, X. Wu, and K. Sandberg Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17{beta}-oestradiol regulation of renal pathology in renal wrap hypertension in rats Exp Physiol, May 1, 2008; 93(5): 648 - 657. [Abstract] [Full Text] [PDF]