AJP - Heart Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 293: H590-H598, 2007. First published March 23, 2007; doi:10.1152/ajpheart.00047.2007
0363-6135/07 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
293/1/H590    most recent
00047.2007v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dedkov, E. I.
Right arrow Articles by Tomanek, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dedkov, E. I.
Right arrow Articles by Tomanek, R. J.

Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infarcted rats is associated with decrease in perivascular collagen

Eduard I. Dedkov,1 Wei Zheng,1 Lance P. Christensen,1 Robert M. Weiss,2,3,4 Florence Mahlberg-Gaudin,5 and Robert J. Tomanek1,3

1Department of Anatomy and Cell Biology, 2Internal Medicine, and 3Cardiovascular Center, University of Iowa Carver College of Medicine; 4Department of Veterans Affairs Medical Center, Iowa City, Iowa; and 5Institut de Recherches Internationales Servier, Courbevoie, France

Submitted 12 January 2007 ; accepted in final form 21 March 2007

We tested the hypothesis that chronically reducing the heart rate in infarcted middle-aged rats using ivabradine (IVA) would induce arteriolar growth and attenuate perivascular collagen and, thereby, improve maximal perfusion and coronary reserve in the surviving myocardium. Myocardial infarction (MI) was induced in 12-mo-old male Sprague-Dawley rats, which were then treated with either IVA (10.5 mg·kg–1·day–1; MI + IVA) or placebo (MI) via intraperitoneal osmotic pumps for 4 wk. Four weeks of IVA treatment limited the increase in left ventricular end-diastolic pressure and the decrease in ejection fraction but did not affect the size of the infarct, the magnitude of myocyte hypertrophy, or the degree of arteriolar and capillary growth. However, treatment reduced interstitial and periarteriolar collagen in the surviving myocardium of MI + IVA rats. The reduced periarteriolar collagen content was associated with improvement in maximal myocardial perfusion and coronary reserve. Although the rates of proliferation of periarteriolar fibroblasts were similar in the MI and MI + IVA groups, the expression levels of the AT1 receptor and transforming growth factor (TGF)-beta1 in the myocardium, as well as the plasma level of the ANG II peptide, were lower in treated rats 14 days after MI. Therefore, our data reveal that improved maximal myocardial perfusion and coronary reserve in MI + IVA rats are most likely the result of reduced periarteriolar collagen rather than enhanced arteriolar growth.

myocardial infarction; coronary circulation; coronary vessels; renin-angiotensin system


Address for reprint requests and other correspondence: E. I. Dedkov, Dept. of Biomedical Sciences, NYCOM I Bldg., Rm. 215E, New York College of Osteopathic Medicine/NYIT, Old Westbury, NY 11568 (e-mail: ededkov{at}nyit.edu)




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. P. Christensen, R.-l. Zhang, W. Zheng, J. J. Campanelli, E. I. Dedkov, R. M. Weiss, and R. J. Tomanek
Postmyocardial infarction remodeling and coronary reserve: effects of ivabradine and beta blockade therapy
Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H322 - H330.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Milliez, S. Messaoudi, J. Nehme, C. Rodriguez, J.-L. Samuel, and C. Delcayre
Beneficial effects of delayed ivabradine treatment on cardiac anatomical and electrical remodeling in rat severe chronic heart failure
Am J Physiol Heart Circ Physiol, February 1, 2009; 296(2): H435 - H441.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
G. Heusch, A. Skyschally, P. Gres, P. van Caster, D. Schilawa, and R. Schulz
Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction
Eur. Heart J., September 2, 2008; 29(18): 2265 - 2275.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Maczewski and U. Mackiewicz
Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart
Cardiovasc Res, July 1, 2008; 79(1): 42 - 51.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
G. M. De Ferrari, A. Mazzuero, L. Agnesina, A. Bertoletti, M. Lettino, C. Campana, P. J. Schwartz, and L. Tavazzi
Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure
Eur J Heart Fail, June 1, 2008; 10(6): 550 - 555.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
V. Ciobotaru, M. Heimburger, L. Louedec, C. Heymes, R. Ventura-Clapier, P. Bedossa, B. Escoubet, J.-B. Michel, J.-J. Mercadier, and D. Logeart
Effect of Long-Term Heart Rate Reduction by If Current Inhibition on Pressure Overload-Induced Heart Failure in Rats
J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 43 - 49.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2007 by the American Physiological Society.