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Speckle-tracking strain echocardiography for detecting cardiac dyssynchrony in a canine model of dyssynchrony and heart failure

¹Division of Cardiology, Department of Medicine, ²Division of Cardiothoracic Surgery, Department of Surgery, and ³Carlyle Fraser Heart Center, Emory University School of Medicine, Emory University, Atlanta, Georgia

Submitted 9 February 2007 ; accepted in final form 16 April 2007

Multiple echocardiographic criteria have been proposed to diagnose mechanical dyssynchrony in patients with heart failure without being validated against a model of cardiac dyssynchrony with heart failure. This study examines which of these methods can detect dyssynchrony in a canine model. Adult mongrel dogs underwent His-bundle ablation and right-ventricular pacing for 4 wk at either 110 bpm to induce dyssynchrony without heart failure (D group, n = 12) or 170 bpm to induce dyssynchrony with heart failure (DHF group, n = 9). To induce heart failure with narrow QRS, atria were paced at 190 bpm for 4 wk (HF group, n = 8). Tissue Doppler imaging (TDI) and two-dimensional echocardiography were performed at baseline and at end of study. Standard deviation of time to peak systolic velocity (color-coded TDI), time to peak S wave on pulse-wave TDI, time to peak radial and circumferential strain by speckle-tracking analysis (E_rr and E_cc, respectively), and septal-to-posterior wall motion delay on M mode were obtained. In D group, only E_rr and E_cc were increased by dyssynchrony. In contrast, all the echocardiographic parameters of dyssynchrony appeared significantly augmented in the DHF group. Receiver-operator curve analysis showed good sensitivity of E_rr (90%) and E_cc (100%) to detected dyssynchrony without heart failure and excellent sensitivity and specificity of E_rr and E_cc to detect dyssynchrony with heart failure. Radial strain by speckle tracking is more accurate than TDI velocity to detect cardiac dyssynchrony in a canine model of dyssynchrony with or without heart failure.

tissue Doppler; strain

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