HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 293/2/H968    most recent 00891.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Lee, T.-M. Articles by Chang, N.-C. Search for Related Content PubMed PubMed Citation Articles by Lee, T.-M. Articles by Chang, N.-C.

Inhibition of histone deacetylase on ventricular remodeling in infarcted rats

¹Cardiology Section, Department of Medicine, Taipei Medical University and Chi-Mei Medical Center, Tainan; ²Department of Pharmacy, National Taiwan University and Hospital, Taipei; and ³Cardiology Section, Department of Medicine, Taipei Medical University and Hospital, Taipei, Taiwan

Submitted 18 August 2006 ; accepted in final form 7 March 2007

Histone deacetylase (HDAC) determines the acetylation status of histones and, thereby, controls the regulation of gene expression. HDAC inhibitors have been shown to inhibit cardiomyocyte growth in vitro and in vivo. We assessed whether HDAC inhibitors exert a beneficial effect on the remodeling heart in infarcted rats. At 24 h after ligation of the left anterior descending artery, male Wistar rats were randomized to vehicle, HDAC inhibitors [valproic acid (VPA) and tributyrin], an agonist of HDAC (theophylline), VPA + theophylline, or tributyrin + theophylline for 4 wk. Significant ventricular hypertrophy was detected as increased myocyte size at the border zone isolated by enzymatic dissociation after infarction. Cardiomyocyte hypertrophy and collagen formation at the remote region and border zone were significantly attenuated by VPA and tributyrin with a similar potency compared with that induced by the vehicle. Left ventricular shortening fraction was significantly higher in the VPA- and tributyrin-treated groups than in the vehicle-treated group. Increased synthesis of atrial natriuretic peptide mRNA after infarction was confirmed by RT-PCR, consistent with the results of immunohistochemistry and Western blot for acetyl histone H4. The beneficial effects of VPA and tributyrin were abolished by theophylline, implicating HDAC as the relevant target. Inhibition of HDAC by VPA or tributyrin can attenuate ventricular remodeling after infarction. This might provide a worthwhile therapeutic target.

hypertrophy; infarction

This article has been cited by other articles:

				C.-S. Kang, C.-C. Chen, C.-C. Lin, N.-C. Chang, and T.-M. Lee Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts Am J Physiol Heart Circ Physiol, June 1, 2009; 296(6): H1949 - H1959. [Abstract] [Full Text] [PDF]

				A. Granger, I. Abdullah, F. Huebner, A. Stout, T. Wang, T. Huebner, J. A. Epstein, and P. J. Gruber Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice FASEB J, October 1, 2008; 22(10): 3549 - 3560. [Abstract] [Full Text] [PDF]