HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 293/4/H2296    most recent 00194.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Ayalew-Pervanchon, A. Articles by Grynberg, A. Search for Related Content PubMed PubMed Citation Articles by Ayalew-Pervanchon, A. Articles by Grynberg, A.

Long-term effect of dietary -linolenic acid or decosahexaenoic acid on incorporation of decosahexaenoic acid in membranes and its influence on rat heart in vivo

¹Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1154, Lipides Membranaires et Régulation Fonctionnelle du Cœur et des Vaisseaux, Châtenay-Malabry, France; ²Université Paris-Sud, Faculté de Pharmacie, Institut Fédératif de Recherches 141, Châtenay-Malabry, France; ³Laboratoire de Pathophysiologie et Pharmacologie Cardiovasculaires Expérimentales, Faculté de Médecine, Dijon, France; ⁴Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France; and ⁵Société VALOREX, Combourtillé, France

Submitted 14 February 2007 ; accepted in final form 21 May 2007

The present study was designed to evaluate whether long-term intake of dietary -linolenic acid (ALA), supplied as whole grain-extruded linseed, can increase endogenous production of n-3 long-chain polyunsaturated fatty acids (FAs) in healthy adult rats and influence the heart rate (HR) and adrenergic response in the same way as docosahexaenoic acid (DHA)-rich diets. DHA enrichment was evaluated using FA analysis of tissue phospholipids after 8, 16, 24, and 32 wk of feeding in male Wistar rats randomly assigned to three dietary groups (n = 8 in each group): a reference fat diet (RFD), an ALA-rich (ALA) diet, and a DHA-rich (DHA) diet. At 1 wk before the animals were killed, under anesthesia, HR was measured from ECG recordings during an adrenergic stimulation challenge (n = 8). There was a significant increase of DHA in the cardiac membrane in the ALA group compared with the RFD group. DHA content in the cardiac membrane was 10% in the ALA group vs. 20% in the DHA group and 4% in the RFD group. The cardiac FA profile was established after 2 mo and remained essentially unchanged thereafter. Regardless of the diet, DHA in the heart decreased with age. Nevertheless, DHA content in the heart remained at >15% in the DHA group and remained greater in older rats fed the ALA diet than in younger RFD-fed rats. Basal HR decreased in the ALA group (395 ± 24.9 beats/min) to a level between that of the DHA and RFD groups (375 ± 26.4 and 407 ± 36.7 beats/min, respectively). Both n-3 dietary intakes contribute to enhancement of the chronotropic response to adrenergic agonist stimulation. Regulation of HR by neurohumoral mediators may be controlled by lower content of DHA, e.g., by a dietary supply of extruded linseed (ALA).

cardiac docosahexaenoic acid; heart function

This article has been cited by other articles:

				V. Robbez Masson, A. Lucas, A.-M. Gueugneau, J.-P. Macaire, J.-L. Paul, A. Grynberg, and D. Rousseau Long-Chain (n-3) Polyunsaturated Fatty Acids Prevent Metabolic and Vascular Disorders in Fructose-Fed Rats J. Nutr., October 1, 2008; 138(10): 1915 - 1922. [Abstract] [Full Text] [PDF]

				M. Igarashi, K. Ma, L. Chang, J. M. Bell, and S. I. Rapoport Rat heart cannot synthesize docosahexaenoic acid from circulating {alpha}-linolenic acid because it lacks elongase-2 J. Lipid Res., August 1, 2008; 49(8): 1735 - 1745. [Abstract] [Full Text] [PDF]