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This Article Full Text Full Text (PDF) Supplemental Tables All Versions of this Article: 293/6/H3366    most recent 00042.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Spielmann, N. Articles by Bouchard, C. Search for Related Content PubMed PubMed Citation Articles by Spielmann, N. Articles by Bouchard, C.

Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study

¹Pennington Biomedical Research Center, Human Genomics Laboratory, Louisiana State University System, Baton Rouge, Louisiana; ²School of Kinesiology, University of Minnesota, Minneapolis, Minnesota; ³Division of Biostatistics and ⁴Departments of Genetics and Psychiatry, Washington University School of Medicine, St. Louis, Missouri; and ⁵Department of Kinesiology, Indiana University, Bloomington, Indiana

Submitted 10 January 2007 ; accepted in final form 3 October 2007

The purpose of this study was to identify regions of the human genome linked to submaximal exercise heart rates in the sedentary state and in response to a standardized 20-wk endurance training program in blacks and whites of the HERITAGE Family Study. A total of 701 polymorphic markers covering the 22 autosomes were used in the genome-wide linkage scan, with 328 sibling pairs from 99 white nuclear families and 102 pairs from 115 black family units. Steady-state heart rates were measured at the relative intensity of 60% maximal oxygen uptake (HR60) and at the absolute intensity of 50 W (HR50). Baseline phenotypes were adjusted for age, sex, and baseline body mass index (BMI) and training responses (posttraining minus baseline, ) were adjusted for age, sex, baseline BMI, and baseline value of the phenotype. Two analytic strategies were used, a multipoint variance components and a regression-based multipoint linkage analysis. In whites, promising linkages (LOD > 1.75) were identified on 18q21-q22 for baseline HR50 (LOD = 2.64; P = 0.0002) and HR60 (LOD = 2.10; P = 0.0009) and on chromosome 2q33.3 for HR50 (LOD = 2.13; P = 0.0009). In blacks, evidence of promising linkage for baseline HR50 was detected with several markers within the chromosomal region 10q24-q25.3 (peak LOD = 2.43, P = 0.0004 with D10S597). The most promising regions for fine mapping in the HERITAGE Family Study were found on 2q33 for HR50 training response in whites, on 10q25-26 for baseline HR60 in blacks, and on 18q21–22 for both baseline HR50 and HR60 in whites.

exercise training; linkage; quantitative trait loci; genotype