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Am J Physiol Heart Circ Physiol 294: H220-H228, 2008. First published November 2, 2007; doi:10.1152/ajpheart.00968.2007
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Characterization of agonist-induced vasoconstriction in mouse pulmonary artery

Minlin Xu,1 Oleksandr Platoshyn,1 Ayako Makino,1 Wolfgang H. Dillmann,1 Katerina Akassoglou,2 Carmelle V. Remillard,1 and Jason X.-J. Yuan1

Departments of 1Medicine and 2Pharmacology, University of California, San Diego, La Jolla, California

Submitted 21 August 2007 ; accepted in final form 30 October 2007

In recent years, transgenic mouse models have been developed to examine the underlying cellular and molecular mechanisms of lung disease and pulmonary vascular disease, such as asthma, pulmonary thromboembolic disease, and pulmonary hypertension. However, there has not been systematic characterization of the basic physiological pulmonary vascular reactivity in normal and transgenic mice. This represents an intellectual "gap", since it is important to characterize basic murine pulmonary vascular reactivity in response to various contractile and relaxant factors to which the pulmonary vasculature is exposed under physiological conditions. The present study evaluates excitation- and pharmacomechanical-contraction coupling in pulmonary arteries (PA) isolated from wild-type BALB/c mice. We demonstrate that both pharmaco- and electromechanical coupling mechanisms exist in mice PA. These arteries are also reactive to stimulation by {alpha}1-adrenergic agonists, serotonin, endothelin-1, vasopressin, and U-46619 (a thromboxane A2 analog). We conclude that the basic vascular responsiveness of mouse PA is similar to those observed in PA of other species, including rat, pig, and human, albeit on a different scale and to varying amplitudes.

pharmacology; store depletion; excitation-contraction coupling; G protein-coupled receptors


Address for reprint requests and other correspondence: J. X.-J. Yuan, Division of Pulmonary and Critical Care Medicine, Dept. of Medicine, Univ. of California, San Diego, 9500 Gilman Dr., MC 0725, La Jolla, CA 92093–0725 (e-mail: xiyuan{at}ucsd.edu)




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M. Xu, C. V. Remillard, B. D. Sachs, A. Makino, O. Platoshyn, W. Yao, W. H. Dillmann, K. Akassoglou, and J. X.-J. Yuan
p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction
Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1529 - H1538.
[Abstract] [Full Text] [PDF]


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