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Am J Physiol Heart Circ Physiol 294: H551-H569, 2008. First published December 14, 2007; doi:10.1152/ajpheart.01036.2007
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INVITED REVIEW

Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice

Chunyu Zeng,1 Ines Armando,2 Yingjin Luo,2 Gilbert M. Eisner,3 Robin A. Felder,4 and Pedro A. Jose2,5

1Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, People's Republic of China; Departments of 2Pediatrics and 3Medicine, Georgetown University Medical Center, Washington, District of Columbia; 4Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, Virginia; 5Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, District of Columbia

Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones/humoral factors, such as aldosterone, angiotensin, catecholamines, endothelin, oxytocin, prolactin pro-opiomelancortin, reactive oxygen species, renin, and vasopressin. Dopamine receptors are classified into D1-like (D1 and D5) and D2-like (D2, D3, and D4) subtypes based on their structure and pharmacology. In recent years, mice deficient in one or more of the five dopamine receptor subtypes have been generated, leading to a better understanding of the physiological role of each of the dopamine receptor subtypes. This review summarizes the results from studies of various dopamine receptor mutant mice on the role of individual dopamine receptor subtypes and their interactions with other G protein-coupled receptors in the regulation of blood pressure.

knockout mice; dopamine receptor


Address for reprint requests and other correspondence: C. Zeng, Dept. of Cardiology, Daping Hospital, The Third Military Medical Univ., Chongqing City 400042, People's Republic of China (e-mail: cyzeng1{at}hotmail.com)






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