AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 295: H842-H850, 2008. First published June 20, 2008; doi:10.1152/ajpheart.91426.2007
0363-6135/08 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
295/2/H842    most recent
91426.2007v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Soto, P. F.
Right arrow Articles by Gropler, R. J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Soto, P. F.
Right arrow Articles by Gropler, R. J.

Exercise training impacts the myocardial metabolism of older individuals in a gender-specific manner

Pablo F. Soto,1,3 Pilar Herrero,3 Kenneth B. Schechtman,4 Alan D. Waggoner,1 Jeffrey M. Baumstark,3 Ali A. Ehsani,1,2 and Robert J. Gropler1,3

1Cardiovascular Division and 2Division of Geriatrics and Nutritional Sciences, Department of Medicine, 3Department of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, and 4Department of Biostatistics, Washington University School of Medicine, St. Louis, Missouri

Submitted 12 December 2007 ; accepted in final form 16 June 2008

Aging is associated with decreases in aerobic capacity, cardiac function, and insulin sensitivity as well as alterations in myocardial substrate metabolism. Endurance exercise training (EET) improves cardiac function in a gender-specific manner, and EET has been shown to improve whole body glucose tolerance, but its effects on myocardial metabolism are unclear. Accordingly, we studied the effect of EET on myocardial substrate metabolism in older men and women. Twelve healthy older individuals (age: 60–75 yr; 6 men and 6 women) underwent PET with [15O]water, [11C]acetate, [11C]glucose, and [11C]palmitate for the assessment of myocardial blood flow (MBF), myocardial O2 consumption (MVO2), myocardial glucose utilization (MGU), and myocardial fatty acid utilization (MFAU), respectively, at rest and during dobutamine infusion (10 µg·kg–1·min–1). Measurements were repeated after 11 mo of EET. Maximal O2 uptake (VO2max) increased (P = 0.005) after EET. MBF was unaffected by training, as was resting MVO2; however, posttraining dobutamine MVO2 was significantly higher (P = 0.05), as was MGU (P < 0.04). Although overall dobutamine MFAU was unchanged, posttraining dobutamine MFAU increased in women (P = 0.01) but decreased in men (P = 0.03). Thus, EET in older individuals improves the catecholamine response of myocardial glucose metabolism. Moreover, gender differences exist in the myocardial fatty acid metabolic response to training. These findings suggest a role for altered myocardial substrate metabolism in modulating the cardiovascular benefits of EET in older individuals.

aging; catecholamine; fatty acid; glucose; insulin resistance


Address for reprint requests and other correspondence: P. F. Soto, Cardiovascular Div., Washington Univ. School of Medicine, Campus Box 8225, 660 S. Euclid Ave., St. Louis, MO 63110 (e-mail: sotop{at}mir.wustl.edu)






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2008 by the American Physiological Society.