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This Article Full Text Full Text (PDF) All Versions of this Article: 297/1/H125    most recent 00165.2009v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Radovits, T. Articles by Szabó, G. PubMed PubMed Citation Articles by Radovits, T. Articles by Szabó, G.

Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus

Tamás Radovits,^1,2 Sevil Korkmaz,¹ Sivakkanan Loganathan,¹ Enik Barnucz,¹ Timo Bömicke,¹ Rawa Arif,¹ Matthias Karck,¹ and Gábor Szabó¹

¹Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany; and ²Department of Cardiology, Heart Center, Semmelweis University, Budapest, Hungary

Submitted 19 February 2009 ; accepted in final form 8 May 2009

Diabetes mellitus (DM) is associated with characteristic structural and functional changes of the myocardium, termed diabetic cardiomyopathy. As a distinct entity independent of coronary atherosclerosis, diabetic cardiomyopathy is an increasingly recognized cause of heart failure. A detailed understanding of diabetic cardiac dysfunction, using relevant animal models, is required for the effective prevention and treatment of cardiovascular complications in diabetic patients. We investigated and compared cardiac performance in rat models of type 1 DM (streptozotocin induced) and type 2 DM (Zucker diabetic fatty rats) using a pressure-volume (P-V) conductance catheter system. Left ventricular (LV) systolic and diastolic function was evaluated in vivo at different preloads, including the slope of the end-systolic P-V relation (ESPVR) and end-diastolic P-V relationship (EDPVR), preload recruitable stroke work (PRSW), maximal slope of the systolic pressure increment (dP/dt_max), and its relation to end-diastolic volume (dP/dt_max-EDV) as well as the time constant of LV relaxation and maximal slope of the diastolic pressure decrement. Type 1 DM was associated with decreased LV systolic pressure, dP/dt_max, slope of ESPVR and dP/dt_max-EDV, PRSW, ejection fraction, and cardiac and stroke work indexes, indicating marked systolic dysfunction. In type 2 DM rats, systolic indexes were altered only to a lower extent and the increase of LV stiffness was more pronounced, as indicated by the higher slopes of EDPVR. Our data suggest that DM is characterized by decreased systolic performance and delayed relaxation (mainly in type 1 DM), accompanied by increased diastolic stiffness of the heart (more remarkably in type 2 DM). Based on the sophisticated method of P-V analysis, different characteristics of type 1 and type 2 diabetic cardiac dysfunction can be demonstrated.

systolic dysfunction; diastolic dysfunction; systolic function; diastolic function