AJP - Heart Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 297: H792-H801, 2009. First published May 22, 2009; doi:10.1152/ajpheart.00064.2009
0363-6135/09 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
297/2/H792    most recent
00064.2009v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Potse, M.
Right arrow Articles by Coronel, R.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Potse, M.
Right arrow Articles by Coronel, R.

Validation of a simple model for the morphology of the T wave in unipolar electrograms

Mark Potse,1,2,3,4 Alain Vinet,1,2 Tobias Opthof,3,5 and Ruben Coronel3

1Institute of Biomedical Engineering, Université de Montréal; and 2Research Center, Sacré-Coeur Hospital, Montreal, Quebec, Canada; 3Department of Experimental Cardiology, Center for Heart Failure Research, Academic Medical Center, Amsterdam; and 4Interuniversity Cardiology Institute of the Netherlands; and 5Department of Medical Physiology, University Medical Center, Utrecht, The Netherlands

Submitted 21 January 2009 ; accepted in final form 14 May 2009

Local unipolar electrograms (UEGs) permit assessment of local activation and repolarization times at multiple sites simultaneously. However, UEG-based indexes of local repolarization are still debated, in particular for positive T waves. Previous experimental and computer modeling studies have not been able to terminate the debate. In this study we validate a simple theoretical model of the UEG and use it to explain how repolarization statistics in the UEG relate to those in the action potential. The model reconstructs the UEG by taking the difference between an inverted local action potential and a position-independent remote signal. In normal tissue, this extremely simple model predicts T-wave morphology with surprising accuracy while explaining in a readily understandable way why the instant of repolarization is always related to the steepest upstroke of the UEG, both in positive and negative T waves, and why positive T waves are related to early repolarizing sites, whereas negative T waves are related to late repolarizing sites.

ventricular repolarization; activation recovery interval; computer model


Address for reprint requests and other correspondence: M. Potse, Research Center, Sacré-Coeur Hospital K3005, 5400 Boulevard Gouin Ouest, Montreal, Quebec, H4J 1C5, Canada (e-mail: mark{at}potse.nl)






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2009 by the American Physiological Society.