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This Article Full Text Full Text (PDF) All Versions of this Article: 297/3/H1010    most recent 01195.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Xiong, Q. Articles by Zhang, J. PubMed PubMed Citation Articles by Xiong, Q. Articles by Zhang, J.

Novel strategy for measuring creatine kinase reaction rate in the in vivo heart

¹Cardiovascular Division, Department of Medicine, and ²Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota

Submitted 14 November 2008 ; accepted in final form 24 June 2009

In the heart, the creatine kinase (CK) system plays an important role in the cascade of ATP production, transportation, and utilization. The forward pseudo-first-order rate constant for the CK reaction can be measured noninvasively by the ³¹P-magnetic resonance (MR) spectroscopy magnetization saturation transfer (MST) techniques. However, the measurement of MST in the in vivo heart is limited by the lengthy data acquisition time, especially for studies requiring spatial localization. This technical report presents a new method for measuring ATP production rate via CK that can reduce the MST data acquisition time by 82%. This method is validated using an in vivo pig model to evaluate the forward pseudo-first-order rate constant of myocardial CK reaction noninvasively.

magnetic resonance spectroscopy; metabolism; high-energy phosphates; adenosine 5'-triphosphate