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Am J Physiol Heart Circ Physiol 297: H1020-H1031, 2009. First published July 2, 2009; doi:10.1152/ajpheart.01082.2008
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Adipose-derived stem cells are an effective cell candidate for treatment of heart failure: an MR imaging study of rat hearts

Lei Wang,1,3,* Jixian Deng,1,* Weichen Tian,3 Bo Xiang,1 Tonghua Yang,1 Gang Li,1,3 Jian Wang,1,3 Marco Gruwel,1 Tarek Kashour,1 John Rendell,1 Miriam Glogowski,1 Boguslaw Tomanek,1 Darren Freed,1,2 Roxanne Deslauriers,1 Rakesh C. Arora,1,2 and Ganghong Tian1

1Institute for Biodiagnostics, National Research Council Canada; 2Cardiac Sciences Program, Saint Boniface General Hospital, University of Manitoba, Winnipeg, Canada; and 3Harbin Medical University, Harbin, People's Republic of China

Submitted 8 October 2008 ; accepted in final form 30 June 2009

This study assessed the potential therapeutic efficacy of adipose-derived stem cells (ASCs) on infarcted hearts. Myocardial infarction was induced in rat hearts by occlusion of the left anterior descending artery (LAD). One week after LAD occlusion, the rats were divided into three groups and subjected to transplantation of ASCs or transplantation of cell culture medium (CCM) or remained untreated. During a 1-mo recovery period, magnetic resonance imaging showed that the ASC-treated hearts had a significantly greater left ventricular (LV) ejection fraction and LV wall thickening than did the CCM-treated and untreated hearts. The capillary density in infarct border zone was significantly higher in the ASC-treated hearts than in the CCM-treated and untreated hearts. However, only 0.5% of the ASCs recovered from the ASC-treated hearts were stained positive for cardiac-specific fibril proteins. It was also found that ASCs under a normal culture condition secreted three cardiac protective growth factors: vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor-1. Results of this study suggest that ASCs were able to improve cardiac function of infarcted rat hearts. Paracrine effect may be the mechanism underlying the improved cardiac function and increased capillary density.

myocardial infarction; magnetic resonance; cardiogenic transdifferentiation


Addressfor reprint requests and other correspondence: G. Tian, National Research Council Canada, Winnipeg, Canada (e-mail: Hong.Tian{at}nrc-cnrc.gc.ca) and R. C. Arora, National Research Council Canada, Winnipeg, Canada (e-mail: rarora{at}sbgh.mb.ca)






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