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This Article Full Text Full Text (PDF) All Versions of this Article: 297/5/H1899    most recent 00433.2009v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Yoshizawa, M. Articles by Tanaka, H. PubMed PubMed Citation Articles by Yoshizawa, M. Articles by Tanaka, H.

Additive beneficial effects of lactotripeptides and aerobic exercise on arterial compliance in postmenopausal women

¹Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, and ²Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan; and ³Department of Kinesiology and Health Education, University of Texas, Austin, Texas

Submitted May 8, 2009 ; accepted in final form September 18, 2009

Central arterial compliance plays an important role in the functional abilities of the vasculature. Two active tripeptides, valine-proline-proline and isoleucine-proline-proline, were isolated from sour milk and were referred to as lactotripeptides (LTP). Because LTP appears to act as an angiotensin-converting enzyme inhibitor, it is plausible to hypothesize that LTP improves arterial compliance. We determined the effects of LTP ingestion alone or in combination with regular aerobic exercise on arterial compliance. A total of 55 postmenopausal women (50–65 yr old) were randomly divided into four groups: placebo, LTP, exercise and placebo (Ex + placebo), or exercise and LTP (Ex + LTP). LTP or placebo was administered orally for 8 wk. The exercise groups completed an 8-wk moderate aerobic exercise intervention. There were no differences in baseline arterial compliance and most other key dependent variables among the groups. Carotid arterial compliance increased significantly in the LTP (0.93 ± 0.07 vs. 0.99 ± 0.08 mm²/mmHg·10^–1), Ex + placebo (0.92 ± 0.04 vs. 1.00 ± 0.05 mm²/mmHg·10^–1), and Ex + LTP groups (0.86 ± 0.06 vs. 1.00 ± 0.06 mm²/mmHg·10^–1), whereas no such changes were observed in the placebo control group (0.86 ± 0.06 vs. 0.85 ± 0.07 mm²/mmHg·10^–1). The magnitude of increases in carotid arterial compliance was significantly greater in the Ex + LTP group (19 ± 4%) than in other groups. The improvements in arterial compliance with LTP were associated with the corresponding reductions in arterial blood pressure and plasma angiotensin II concentrations. We concluded that LTP ingestion improves carotid arterial compliance and that the combination of LTP ingestion and regular exercise is additive and synergistic in improving arterial compliance in postmenopausal women.

fermented milk; peptide; physical activity; lifestyle; arterial stiffness