Am J Physiol Heart Circ Physiol 283: H2004-H2011, 2002;
doi:10.1152/ajpheart.00965.2001
Supplemental Data
for Transmural Reentry Triggered by Epicardial Stimulation during Acute Ischemia in Canine Ventricular Muscle.
Jiashin Wu and Douglas P. Zipes
Krannert Institute of Cardiology
Indiana University School of Medicine
Picture 1. Isolated and arterially perfused transmural wedge from canine left ventricle (top: epicardium, bottom: endocardium). Data were recorded on the cut-exposed transmural surface. The wedge was perfused through plastic tubing inserted into a branch of coronary artery.
Movie 1. (Figure 2C in the paper, Tissue 1). Transmural conduction during epicardial stimulation after 505 seconds of ischemia (top: epicardium, bottom: endocardium). Ischemia depressed conduction more in the epicardium than in the endocardium. The epicardial-initiated activation penetrated the ventricular wall toward the more excitable endocardium, then spread along the endocardium, and back toward the epicardium. At this time, conduction along the epicardium was decremental.
Movie 2. (Figure 2F in the paper, Tissue 1). Transmural conduction during endocardial stimulation after 525 seconds of ischemia (top: epicardium, bottom: endocardium). Switching the site of stimulation to the endocardium 20 seconds later in the same tissue (Movie 1) produced a different pattern of conduction. Activation spread along the endocardium, then slowly across the ventricular wall toward the epicardium.
Movie 3. (Figure 3 in the paper, Tissue 2). Sub-epicardial stimulation initiated transmural reentry after 801 seconds of ischemia (top: epicardium, bottom: endocardium). Activation initiated from the sub-epicardial site of stimulation to the endocardium, along the endocardium, then back to the epicardium.
Copyright © 2002 by the American Physiological Society.
