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Am J Physiol Heart Circ Physiol 291: H2019, 2006. First published May 5, 2006; doi:10.1152/ajpheart.00415.2006
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LETTERS TO THE EDITOR

REPLY

T. K. Bergersen1

Department of Dermatology
Rikshospitalet University Hospital
N-0027 Oslo, Norway

T.W. Hartgill

Ullevaal University Hospital
Department of Obstetrics and Gynecology
University of Oslo
Kirkeveien 166
N-0407 Oslo, Norway

J. Pirhonen

Ullevaal University Hospital
Department of Obstetrics and Gynecology
University of Oslo
Kirkeveien 166
N-0407 Oslo, Norway

To the Editor: We thank Dr. Immink and colleagues (2) for discussion of our study. Their question as to whether this shows preservation of cerebral autoregulation during normal pregnancy uses their own definition of cerebral autoregulation as "the tendency of cerebral blood flow to remain constant over a range of systemic blood pressures." Our study (1) shows that the cerebral blood velocities were unchanged during significant increase in systemic blood pressure in gestational weeks 8, 15, 22, 29, and 36 and 3 mo after birth. We do agree that the mechanisms responsible for this control are complex. However, our findings do suggest that cerebral autoregulation is preserved during pregnancy. Furthermore, as Immink and colleagues state, our study also shows that the cerebral CO2 reactivity is preserved during healthy pregnancy because a vasoconstriction was always seen during significant lowering of the end-tidal CO2.

REFERENCES

  1. Bergersen TK, Hartgill TW, and Pirhonen J. Cerebrovascular response to normal pregnancy: a longitudinal study. Am J Physiol Heart Circ Physiol 290: H1856–H1861, 2006.[Abstract/Free Full Text]
  2. Immink RV, Secher NH, and van Lieshout JJ. Cerebral autoregulation and CO2 responsiveness of the brain. Am J Physiol Heart Circ Physiol 291: H2018, 2006.[Free Full Text]




This Article
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291/4/H2019    most recent
00415.2006v1
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Right arrow Articles by Bergersen, T. K.
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