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CORRIGENDUM

Corrigendum

Volume 61, March 2007

Adebiyi A, Zhao G, Cheranov SY, Ahmed A, Jaggar JH. Caveolin-1 abolishment attenuates the myogenic response in murine cerebral arteries. Am J Physiol Heart Circ Physiol 292: H1584-H1592. First published November 10, 2006; doi:10.1152/ajpheart.00584.2006; http://ajpheart.physiology.org/cgi/content/full/292/3/H1584.

On page H1588, the sentence in the third line of the left column should read as "Total K_Ca channel protein, when normalized to actin, was similar in cav-1^+/+ and cav-1^–/– arteries (Fig. 6, C and D; P > 0.05)." (Corrected text presented in boldface.)

View larger version (24K): [in this window] [in a new window]   Fig. 6. Iberiotoxin induces a similar depolarization and constriction in cav-1+/+ and cav-1–/– arteries, but total arterial KCa channel protein is similar. A: membrane depolarization induced by iberiotoxin (100 nM) is similar in pressurized (50 mmHg) cav-1+/+ (n = 6) and cav-1–/– (n = 6) arteries. B: iberiotoxin (100 nM) induces a similar constriction in cav-1+/+ (n = 6) and cav-1–/– (n = 6) arteries pressurized to 50 mmHg. C: representative Western immunoblots for KCa channel -subunit and actin protein in cav-1+/+ and cav-1–/– cerebral artery lysates. D: mean data illustrating digital densitometric analysis of bands obtained by Western immunoblotting for KCa channel -subunit normalized to actin (n = 4 separate experiments, with each experiment performed using arteries pooled from 4 mice, giving a total of 16 cav-1+/+ and 16 cav-1–/– mice used to obtain data).

View larger version (30K): [in this window] [in a new window]   Fig. 1. Myogenic constriction is attenuated in caveolin-1 (cav-1)–/– arteries. A: Western immunoblot illustrates the presence of cav-1 in cerebral arteries of control mice and the absence of cav-1 in cerebral arteries of cav-1–/– mice (data are representative of 4 experiments). In contrast, actin was detected in both cav-1+/+ and cav-1–/– arteries. B: representative traces illustrate that an elevation in intravascular pressure from 10 to 50 mmHg induces an attenuated myogenic constriction in a cav-1–/– artery, when compared with the response in a cav-1+/+ artery. C: relationship between intravascular pressure and myogenic tone in cav-1+/+ (n = 6) and cav-1–/– (n = 6) arteries. *P < 0.05 when compared with cav-1+/+ arteries at the same pressure. B and D: diltiazem (DTZ) significantly increased the diameter of both cav-1+/+ (n = 6) and cav-1–/– (n = 6) arteries. In the continued presence of DTZ, removal of extracellular Ca2+ did not cause any further increase in diameter. #P < 0.05 when compared with the respective control; P < 0.05 when compared with cav-1+/+ at the same pressure. NS, nonsignificant difference.

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