Submitted on January 2, 2008
Revised on April 15, 2008
Accepted on May 8, 2008
Modeling flow in collecting lymphatic vessels:1d flow through a series of contractile elements
Alison J MacDonald1, Kenton Paul Arkill1*, Gavin R Tabor1, Noel G McHale2, and C Peter Winlove1
1 University of Exeter
2 Dundalk Institute of Technology
* To whom correspondence should be addressed. E-mail: k.p.arkill{at}ex.ac.uk.
The lymphatic system comprises a series of elements, lymphangions, separated by valves and possessed of active, contractile walls to pump interstitial fluid from its collection in the terminal lymphatics back to the main circulation. Despite its importance, there is a dearth of information on the fluid dynamics of the lymphatic system. In this paper we describe linked experimental and computational work aimed at elucidating the biomechanical properties of the individual lymphangions. We measure the static and dynamic mechanical properties of excised bovine collecting lymphatics and develop a 1-d computational model of the coupled fluid flow/wall motion. The computational model is able to reproduce the pumping behavior of the real vessel using a simple contraction function producing fast contraction pulses traveling in the retrograde direction to the flow.
