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1 Cell and Developmental Biology and Anatomy, University of South Carolina, Columbia, South Carolina, United States
* To whom correspondence should be addressed. E-mail: borg{at}med.sc.edu.
Cardiac function is determined by the dynamic interaction of various cell types and the extracellular matrix that compose the heart. This interaction varies with stage of development and the degree and duration of mechanical, chemical and electrical signals between the various cell types and the ECM. Understanding how these complex signals interact at the molecular, cellular and organ levels is critical to understanding function of the heart under a variety of physiological and pathophysiological conditions. Quantitative approaches, both in vivo and in vivo, are essential to understand the dynamic interaction of mechanical, chemical and electrical stimuli that govern cardiac function. The fibroblast can thus be a friend in normal function or a foe in pathophysiological conditions.
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