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Am J Physiol Heart Circ Physiol (April 4, 2002). doi:10.1152/ajpheart.00025.2002
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Articles in PresS, published online ahead of print April 4, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00025.2002
Submitted on January 14, 2002
Accepted on March 26, 2002

Characterization of Myocardial Function using Strain Rate and Strain during Alterations in Inotropic States and Heart Rate

Frank Weidemann1*, Fadi Jamal1, George R. Sutherland1, Piet Claus1, Miroslaw Kowalski1, Liv Hatle1, Ivan De Scheerder1, Bart Bijnens1, and Frank E. Rademakers1

1 Department of Cardiology, University hospital Gasthuisberg, Leuven, Belgium

* To whom correspondence should be addressed. E-mail: f.weidemann{at}medizin.uni-wuerzburg.de.

For porcine myocardium, ultrasonic regional deformation parameters, systolic strain ({epsilon}SYS) and peak systolic strain rate (SRSYS) were compared to stroke volume (SV) and contractility (CI) measured as the ratio of end-systolic strain / end-systolic wall-stress. Heart rate (HR) and contractility were varied by atrial pacing (AP=100-80/min, n=7), incremental dobutamine infusion (DI=2.5-20 mg/kg/min, n=7) or continuous esmolol infusion (0.5 mg/kg/min) + subsequent pacing (100-180/min) (EI group, n=6). Baseline (BL) SRSYS and {epsilon}SYS averaged 5.0±0.4 sec-1 and 60±4 %. SRSYS and CI increased linearly with DI (20 µg/kg/min: SRSYS =9.9±0.7 sec-1, p<0.0001) and decreased with EI (SRSYS=3.4±0.1 sec-1, p<0.01). During pacing, SRSYS and CI remained unchanged in the AP and EI groups. During DI, {epsilon}SYS and SV initially increased (5µg/kg/min: {epsilon}SYS=77±6%, p<0.01), then progressively returned to BL. During EI, SV and {epsilon}SYS decreased ({epsilon}SYS=38±2%, p<0.001). Pacing also decreased SV and {epsilon}SYS in the AP (180/min: {epsilon}SYS=36±2%, p<0.001) and EI groups (180/min: {epsilon}SYS=25±3%, p<0.001). Thus, for normal myocardium, SRSYS reflects regional contractile function (being relatively independent of HR) while {epsilon}SYS reflects changes in SV.




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