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1 Anatomy & Physiology, Kansas State University, Manhattan, KS, USA
* To whom correspondence should be addressed. E-mail: kenny{at}vet.ksu.edu.
In the present study we established dose-response relationships between central tempol (superoxide dismutase mimetic) administration and the level of renal sympathetic nerve discharge (SND) and tested the hypothesis that intracerebroventricular (icv) tempol pretreatment would attenuate centrally-mediated changes in SND produced by icv angiotensin II (Ang II) administration. Urethane-chloralose anesthetized, baroreceptor-denervated, normotensive rats were used. ICV tempol produced dose-dependent sympathoinhibitory, hypotensive, and bradycardic responses. Mean arterial pressure and SND were significantly increased after icv Ang II (150 ng/kg) administration, responses that were abrogated after icv pretreatment with tempol (75 µmol/kg) or losartan. Brain superoxide levels tended to be higher in Ang II-treated compared with tempol+Ang II-treated rats. Tempol pretreatment did not prevent increases in SND produced by acute heat stress, indicating specificity in the effect of tempol in reducing sympathoexcitation. These results demonstrate that icv tempol administration influences central sympathetic neural circuits in a dose-dependent manner and attenuates SND responses to central Ang II infusion.
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