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Am J Physiol Heart Circ Physiol (June 27, 2002). doi:10.1152/ajpheart.00041.2002
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Articles in PresS, published online ahead of print June 27, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00041.2002
Submitted on January 20, 2002
Accepted on June 20, 2002

Reactive Oxygen Species Generated During Myocardial Ischemia Enable Energetic Recovery During Reperfusion

Paul F. Klawitter1*, Holt N. Murray1, Thomas L. Clanton2, and Mark G. Angelos1

1 Emergency Medicine, The Ohio State University, Columbus, OH, USA
2 Internal Medicine, Division of Pulmonary and Critical Care, The Ohio State University, Columbus, OH, USA

* To whom correspondence should be addressed. E-mail: Klawitter.1{at}osu.edu.

Abstract: Differences between the functional and bioenergetic effects of antioxidants (AOX) administered before or after myocardial ischemia was studied. Sprague-Dawley rat hearts were perfused with a modified Krebs-Henseleit solution, bubbled with 95%/5% O2/CO2. The protocol consisted of 10 min of baseline perfusion, 20 min of global ischemia and 30 min reperfusion. An AOX, either Tiron (1,2-dihydroxybenzene-3,5-disulfonate), a superoxide scavenger, or N-acetyl cysteine (NAC), was infused during either baseline or reperfusion. An additional group received deferoxamine as a bolus prior to ischemia. Hearts were freeze-clamped at baseline, end of ischemia and end of reperfusion for analysis of high-energy phosphates. All AOX when given prior to ischemia inhibited recovery of [ATP] compared to controls. Both Tiron and deferoxamine also inhibited recovery of [PCr]. AOXs given prior to ischemia decreased efficiency of contraction during reperfusion, compared to controls. All the changes in energetics and efficiency brought on by preischemic AOX treatment could be blocked by a preconditioning stimulus. This suggests that ROS, generated during ischemia, enhance bioenergetic recovery by increasing the efficiency of contraction




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