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Am J Physiol Heart Circ Physiol (March 18, 2005). doi:10.1152/ajpheart.00061.2005
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Submitted on January 20, 2005
Accepted on March 15, 2005

Dietary isoflavones during pregnancy and lactation provide cardioprotection to offspring rats in adulthood

Emmanuelle Souzeau1, Sonia Belanger1, Sylvie Picard1, and Christian F Deschepper1*

1 Experimental Cardiovascular Biology Research Unit, Institut de recherches cliniques de Montreal, Montreal, QC, Canada

* To whom correspondence should be addressed. E-mail: deschec{at}ircm.qc.ca.

In adult rats, elongation of cardiac myocytes correlates with dilatation (and sometimes dysfunction) of cardiac ventricles. Although sex steroids may constitute one possible factor that affects the dimensions of CMs, studies on their effects in rodents is complicated by the fact that most commercial soy-based diets also contain abundant phytoestrogens. We report that feeding WKY rat dams during gestation and lactation with a phytoestrogen-rich soy-based diet caused the cardiomyocytes of their adult offspring to be shorter than in counterparts originating from mothers fed with a phytoestrogen-free casein-based diet. The soy-based diet had no such effects when given to rats after 6 weeks of age, and its effects were replicated when supplementing maternal casein-based diet with the isoflavones daidzein and genistein (the most abundant phytoestrogens in soy-based diet). In contrast to rats whose mothers had been fed with soy-based diet, the hearts of adult rats raised with casein-based diet only featured dilated eccentric hypertrophy and progressed towards congestive heart failure when further challenged. Thus, the presence of isoflavones in the maternal diet provides cardioprotection to the hearts of their offspring during adulthood.




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