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Articles in PresS, published online ahead of print May 16, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00074.2002
Submitted on January 31, 2002
Accepted on May 10, 2002
1 Chemical and Biological Engineering, Tufts University, Medford, MA, USA
* To whom correspondence should be addressed. E-mail: aurelie.edwards{at}tufts.edu.
In this model of oxygen transport in the renal medullary microcirculation, we predicted that the net amount of oxygen reabsorbed from vasa recta into the interstitium is on the order of 10-6 mmol/s, i.e., significantly lower than estimated medullary oxygen requirements based upon active sodium reabsorption. Our simulations confirmed a number of experimental findings. Low medullary oxygen tension (PO2) results from the counter-current arrangement of vessels, an elevated vasa recta permeability to oxygen, as well as high metabolic needs. Diffusional shunting of oxygen between DVR and AVR also explains why a 20 mmHg decrease in initial PO2 at the cortico-medullary junction only leads to a small drop in papillary tip PO2 (<2 mmHg with baseline parameter values). Conversely, small changes in the consumption rate of DVR-supplied oxygen, in blood flow rate, in hematocrit, or in capillary permeability to oxygen, beyond certain values sharply reduce interstitial PO2. Without erythrocytes, papillary tip PO2 cannot be maintained above 10 mmHg, even when oxygen consumption is zero.
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