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1 Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France; Inserm E 0226, Université Claude Bernard Lyon I, Lyon, France
2 Inserm E 0226, Université Claude Bernard Lyon I, Lyon, France
3 Cardiology, University Hospital of RENNES, RENNES, France
4 Cardiolgy, Hôpital Charles Nicolle, Rouen, France
5 Cardiac Ultrasound Laboratory, Harvard, Boston, Massachusetts, United States
6 Inserm E0226, United States; Inserm E 0226, Université Claude Bernard Lyon I, Lyon, France; Inserm E0226; Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France
7 Inserm E 0226, Université Claude Bernard Lyon I, Lyon, France; Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France
* To whom correspondence should be addressed. E-mail: genevieve.derumeaux{at}chu-lyon.fr.
In vivo evaluation of the transmural extent of myocardial infarction (TEI) is crucial to predict viability and prognosis. With the rise of transgenic technology, myocardial infarction (MI) murine models are increasingly used.
Our study aimed to evaluate systolic strain rate (SR), a new parameter of regional function, to quantify TEI in a murine model of acute MI induced by various durations of ischemia followed by 24 hours of reperfusion.
Global and regional left ventricular (LV) function was assessed by echocardiography (13 MHz, Vivid 7, GE) in 4 groups of wild type mice (C57BL6, 2 months old): a sham group (n=10) and 3 MI groups (30 (n=11), 60 (n=10) and 90 (n=9) minutes of LAD occlusion).
Conventional LV dimensions, anterior wall (AW) thickening and peak systolic SR were measured, before and 24 hours after reperfusion. The area at risk (AR) was measured by blue dye and the infarct size (AN) and the TEI by TTC staining.
AN increased with ischemia duration (25±2, 56±5, 71±6 % of the AR, p
0.05). LV end-diastolic volume significantly increased with ischemia duration (30±5, 34±5, 43±5 µl, p0.05) whereas LV ejection fraction decreased (63±5, 58±6, 46±5%, p0.05). AW thickening decrease was not influenced by ischemia duration. Conversely, systolic SR decreased with ischemia duration (13±5, 4±3, -2±6 s-1, p0.05) and was significantly correlated with TEI (r=0.89, p0.01). ROC curves identified systolic SR as the most accurate parameter to predict TEI.
In conclusion, in a murine model of MI, SR imaging is superior to conventional echocardiography to predict the TEI early after MI.
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 G. Derumeaux, F. Ichinose, M. J. Raher, J. G. Morgan, T. Coman, C. Lee, J. M. Cuesta, H. Thibault, K. D. Bloch, M. H. Picard, et al. Myocardial Alterations in Senescent Mice and Effect of Exercise Training: A Strain Rate Imaging Study Circ Cardiovasc Imaging, November 1, 2008; 1(3): 227 - 234. [Abstract] [Full Text] [PDF]
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