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1 Belo Horizonte, Minas Gerais, Brazil; Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil
2 Department of Cardiology and Pneumonology, Charite-Universitatsmedizin, Berlin, Germany
3 Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil
4 Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
* To whom correspondence should be addressed. E-mail: mjcs{at}icb.ufmg.br.
The G-protein coupled receptor Mas was recently described as an angiotensin-(1-7) [Ang-(1-7)] receptor. In the present study we evaluated the anatomical localization of Mas using immunofluorescence in central nervous system of adult male Wistar rats. An abundant labeling was found in the hippocampus, amigdala, anterodorsal thalamic nucleus, cortex and in the hypoglossal nucleus. More importantly, a dense Ang-(1-7) receptor Mas immunoreactivity was observed in cardiovascular-related areas of the medulla and forebrain, shown in several previous studies as sites for the action of Ang-(1-7) in the brain. A strong staining was found in the nucleus of the solitary tract, caudal and rostral ventrolateral medulla, inferior olive, in parvo and magnocellular portions of the paraventricular hypothalamic nucleus, in the supraoptic nucleus and in the lateral preoptic area. Further, Mas staining was predominantly present in neurons. At the medullary sites, a specific and high intensity binding for Rhodamine-Ang-(1-7) was also shown. The specific Ang-(1-7) binding was completely displaced by the anti-Mas antibody or by the Ang-(1-7) antagonist, A-779. The data presented provide first anatomical basis for the physiological role of Ang-(1-7)/ Mas axis in the modulation of different cardiovascular functions and give new insights for clarifying the role of Ang-(1-7) in the central nervous system.
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