| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Copenhagen Muscle Research Centre, Copenhagen, Denmark; Department of Infectious Diseases, Rigshospitalet, Copenhagen Muscle Research Centre, Copenhagen, Denmark
2 Copenhagen Muscle Research Centre, Copenhagen, Denmark; University of Copenhagen, August Kroch Institute, Copenhagen, Denmark; University of Copenhagen, August Kroch Institute, Copenhagen, Denmark
* To whom correspondence should be addressed. E-mail: bkp{at}rh.dk.
Angiogenesis, the growth of new blood vessels from existing ones, occurs in skeletal muscle as an adaptive response to exercise that satisfies the increased requirement of this tissue for oxygen delivery and metabolic processes. Of the factors that have been identified to regulate this process, the endothelial cell mitogen vascular endothelial growth factor (VEGF) has been proposed to play a key role. The aim of this study was to measure skeletal muscle VEGF mRNA content and arterial-venous (a-v) protein balance across the working leg in response to a single bout of prolonged, submaximal exercise. Seven physically active males completed 3 h of two-legged kicking ergometry. Muscle biopsies were collected from the vastus lateralis muscle from both working legs, and blood samples were collected from one femoral artery and femoral vein before, during, and in recovery from exercise. We show that the exercise stimulus elicited a decrease in VEGF protein arterial-venous (a-v) balance across the exercising leg (p=0.007), and anine fold elevation in skeletal muscle VEGF mRNA expression (p<0.001). The changes in VEGF protein balance and mRNA content were most pronounced 1 h after the cessation of exercise. In conclusion, these findings demonstrate that sub-maximal exercise, suitable for humans with low CV fitness, induces a decrease in VEGF a-v balance that is likely to be of clinical significance in promoting angiogenic effects.
This article has been cited by other articles:
|
|
 |
|
  E. Rullman, J. Norrbom, A. Stromberg, D. Wagsater, H. Rundqvist, T. Haas, and T. Gustafsson Endurance exercise activates matrix metalloproteinases in human skeletal muscle J Appl Physiol, March 1, 2009; 106(3): 804 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Suhr, K. Brixius, M. de Marees, B. Bolck, H. Kleinoder, S. Achtzehn, W. Bloch, and J. Mester Effects of short-term vibration and hypoxia during high-intensity cycling exercise on circulating levels of angiogenic regulators in humans J Appl Physiol, August 1, 2007; 103(2): 474 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Rullman, H. Rundqvist, D. Wagsater, H. Fischer, P. Eriksson, C. J. Sundberg, E. Jansson, and T. Gustafsson A single bout of exercise activates matrix metalloproteinase in human skeletal muscle J Appl Physiol, June 1, 2007; 102(6): 2346 - 2351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Prior, J. M. Hagberg, C. M. Paton, L. W. Douglass, M. D. Brown, J. C. McLenithan, and S. M. Roth DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1848 - H1855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gustafsson, H. Ameln, H. Fischer, C. J. Sundberg, J. A. Timmons, and E. Jansson VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise J Appl Physiol, June 1, 2005; 98(6): 2137 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Gavin, H. W. Stallings III, K. A. Zwetsloot, L. M. Westerkamp, N. A. Ryan, R. A. Moore, W. E. Pofahl, and R. C. Hickner Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans J Appl Physiol, January 1, 2005; 98(1): 315 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Prior, H. T. Yang, and R. L. Terjung What makes vessels grow with exercise training? J Appl Physiol, September 1, 2004; 97(3): 1119 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Jensen, H. Pilegaard, P. D. Neufer, and Y. Hellsten Effect of acute exercise and exercise training on VEGF splice variants in human skeletal muscle Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R397 - R402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Kraus, H. W. Stallings III, R. C. Yeager, and T. P. Gavin Circulating plasma VEGF response to exercise in sedentary and endurance-trained men J Appl Physiol, April 1, 2004; 96(4): 1445 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Gavin, C. B. Robinson, R. C. Yeager, J. A. England, L. W. Nifong, and R. C. Hickner Angiogenic growth factor response to acute systemic exercise in human skeletal muscle J Appl Physiol, January 1, 2004; 96(1): 19 - 24. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
