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Am J Physiol Heart Circ Physiol (August 22, 2002). doi:10.1152/ajpheart.00164.2002
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Articles in PresS, published online ahead of print August 22, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00164.2002
Submitted on February 27, 2002
Accepted on August 7, 2002

OLFACTORY BULBECTOMY ATTENUATES CARDIOVASCULAR SYMPATHOEXCITATORY REFLEXES IN RATS

Julia A Moffitt1, Angela J Grippo2, Philip V Holmes3, and Alan K Johnson2*

1 Cardiovascular Center, University of Iowa, Iowa City, IA, USA
2 Cardiovascular Center, University of Iowa, Iowa City, IA, USA; Psychology, Pharmacology & Exercise Science, University of Iowa, Iowa City, IA, USA
3 Psychology, University of Georgia, Athens, GA, USA

* To whom correspondence should be addressed. E-mail: alan-johnson{at}uiowa.edu.

Bilateral removal of the olfactory lobes in rats produces a number of behavioral, endocrine, and neurochemical alterations in the brain. Little is known however regarding the effects of this treatment on cardiovascular function and autonomic reflexes. Male Sprague-Dawley rats underwent bilateral surgical ablation of the olfactory bulbs (n=10) or were sham-operated (n=8). Following 3 weeks of recovery, animals were instrumented with femoral catheters and a lumbar sympathetic nerve recording electrode. After 24 hours of recovery, cardiovascular responses to arterial baroreflex manipulation, air-jet stress and smoke exposure were recorded. Olfactory bulbectomized rats demonstrated attenuated sympathoexcitatory responses to hypotension, air-jet stress, and smoke exposure, as well as elevated basal blood pressure, compared to sham-operated rats. These data indicate that integrity of the olfactory bulbs in rats is important for the elicitation of normal cardiovascular and autonomic responses to a number of evocative stimuli.




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