| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print January 31, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00167.2001
Submitted on March 9, 2001
Accepted on January 24, 2002
1 Physiological Sciences, University of Florida, Gainesville, FL, USA
2 Internal Medicine, University of Iowa, Iowa City, IA, USA
3 Internal Medicine, University of Iowa, Iowa City, IA, USA; Research Service, Department of Veterans Affairs Medical Center, Iowa City, IA, USA
* To whom correspondence should be addressed. E-mail: lindah{at}ufl.edu.
We examined the effect of 
-2 adrenoreceptor blockade in the NTS on baroreflex responses elicited by electrical stimulation of the left aortic depressor nerve (ADN) in urethane anesthetized spontaneously hypertensive (SH, n=11) and normotensive Wistar Kyoto (WKY, n=11) rats. ADN stimulation produced a frequency dependent decrease in mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA) and heart rate (HR). In the SH rats, unilateral microinjection of idazoxan into the NTS markedly reduced baroreflex control of MAP, RSNA and HR and had a disproportionately greater influence on baroreflex control of MAP than RSNA. In the WKY rats, idazoxan microinjections did not significantly alter baroreflex function relative to control vehicle injections. These results suggest that baroreflex regulation of arterial pressure in SH rats is highly dependent upon NTS adrenergic mechanisms. The reflex regulation of sympathetic outflow to the kidney is less influenced by the altered -2 adrenoreceptor mechanisms in the SH rat.
This article has been cited by other articles:
|
|
 |
|
  S. T. Yao \#945;-Adrenergic receptors in the nucleus tractus solitarii: fitting a new piece to a complex puzzle Exp Physiol, July 1, 2009; 94(7): 771 - 772. [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. Salgado, A. R. Barale, J. A. Castania, B. H. Machado, M. W. Chapleau, and R. Fazan Jr. Baroreflex responses to electrical stimulation of aortic depressor nerve in conscious SHR Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H593 - H600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kaczynska and M. Szereda-Przestaszewska Clonidine-evoked respiratory effects in anaesthetized rats Exp Physiol, January 1, 2006; 91(1): 269 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Vitela, M. Herrera-Rosales, J. R. Haywood, and S. W. Mifflin Baroreflex regulation of renal sympathetic nerve activity and heart rate in renal wrap hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R856 - R862. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Hermann, J. S. Nasse, and R. C. Rogers {alpha}-1 adrenergic input to solitary nucleus neurones: calcium oscillations, excitation and gastric reflex control J. Physiol., January 15, 2005; 562(2): 553 - 568. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
