| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Cardiology, Kokura Memorial Hospital, Kitakyushu, Fukuoka, Japan
2 Medicine, Meharry Medical College, Nashville, Tennessee, United States
3 Medicine, Cardiology, Emory University School of Medicine, Atlanta, Georgia, United States
4 Carlyle Fraser Heart Center, 30308, Georgia, United States
5 Medicine, Cardiology, Emory University School of Medicine, 30322, Georgia, United States; Carlyle Fraser Heart Center, 30308, Georgia, United States
6 Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia, United States; Carlyle Fraser Heart Center, 30308, Georgia, United States
* To whom correspondence should be addressed. E-mail: dsoresc{at}emory.edu.
Background: Multiple echocardiographic criteria have been proposed to diagnose mechanical dyssynchrony in patients with heart failure without being validated against a model of cardiac dyssynchrony with heart failure. This study examines which of these methods can detect dyssynchrony in a canine model. Methods: Adult mongrel dogs underwent His bundle ablation and right ventricular pacing for 4 weeks at either 110 bpm to induce dyssynchrony without heart failure (D group, n=12) or 170 bpm to induce dyssynchrony with heart failure (DHF group, n=9). To induce heart failure with narrow QRS, atria were paced at 190 bpm for 4 weeks (HF group, n=8). Tissue Doppler imaging (TDI) and 2D echocardiography were performed at baseline and end of the study. Standard deviation of time to peak systolic velocity (color coded TDI), time to peak S wave on pulse wave TDI, time to peak radial and circumferential strain by speckle tracking analysis (tErr-SD, tEcc-SD respectively) as well as septal to posterior wall motion delay on M-mode were obtained. Results: In D group, only tErr-SD and tEcc-SD were increased by dyssynchrony. In contrast, all the echocardiographic parameters of dyssynchrony appeared significantly augmented in the DHF group. Receiver operator curve analysis showed good sensitivity of tErr-SD (90%) and tEcc-SD to (100%) detected dyssynchrony without heart failure and excellent sensitivity and specificity of tErr-SD and tEcc-SD to detect dyssynchrony with heart failure Conclusion: Radial strain by speckle tracking is more accurate than TDI velocity to detect cardiac dyssynchrony in a canine model of dyssynchrony with or without heart failure.
This article has been cited by other articles:
|
|
 |
|
  H.-J. Nesser, V. Mor-Avi, W. Gorissen, L. Weinert, R. Steringer-Mascherbauer, J. Niel, L. Sugeng, and R. M. Lang Quantification of left ventricular volumes using three-dimensional echocardiographic speckle tracking: comparison with MRI Eur. Heart J., July 1, 2009; 30(13): 1565 - 1573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gupta, F. Khan, M. Shapiro, S. G. Weeks, S. E. Litwin, and A. D. Michaels The associations between tricuspid annular plane systolic excursion (TAPSE), ventricular dyssynchrony, and ventricular interaction in heart failure patients Eur J Echocardiogr, November 1, 2008; 9(6): 766 - 771. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
