AJP - Heart Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (June 20, 2002). doi:10.1152/ajpheart.00177.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/4/H1523    most recent
00177.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hoang, D.
Right arrow Articles by Westfall, T. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoang, D.
Right arrow Articles by Westfall, T. C.

Articles in PresS, published online ahead of print June 20, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00177.2001
Submitted on March 12, 2001
Accepted on June 18, 2002

Endothelin Induced Modulation of Neuropeptide Y and Norepinephrine Release from the Rat Mesenteric Bed

Dan Hoang1, Heather Macarthur1, Alice Gardner1, and Thomas C. Westfall1*

1 Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, MO, USA

* To whom correspondence should be addressed. E-mail: westfatc{at}slu.edu.

The effect of three endothelin (ET) agonists (ET-1, ET-3 and sarafotoxin (STX6C) on the nerve stimulation induced release of norepinephrine (NE) and neuropeptide Y immunoreactive compounds (NPY-ir) from the perfused mesenteric arterial bed of the rat as well as the effect on perfusion pressure were examined. ET-1, ET-3 and STX6C all produced a significant, concentration dependent decrease in the evoked release of NPY-ir but had no effect on the release of NE. In contrast all 3 ET's potentiated the nerve stimulation induced increase in perfusion pressure. The inhibition of nerve stimulation induced NPY-ir release by ET-1 was significantly blocked by the ETA/ETB antagonist PD 142893 and the ETB antagonist RES701-1 but not by the ETA antagonist BQ123. The potentiation of the nerve stimulation induced increase in perfusion pressure by ET-1 was significantly blocked by PD142893 and BQ123 and attenuated by RES701-1. Prior exposure of the preparation to indomethacin or meclofenamate failed to alter the attenuation of the evoked release of NPY-ir or the potentiation of the increase in perfusion pressure produced by ET-1 or ET-3. These results are consistent with the idea that sympathetic co-transmitters can be preferentially modulated by paracrine mediators at the vascular neuroeffector junction.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. D'Angelo, J. S. Pollock, and D. M. Pollock
In vivo evidence for endothelin-1-mediated attenuation of {alpha}1-adrenergic stimulation
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1251 - H1258.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. Backs, E. Bresch, M. Lutz, A. V. Kristen, and M. Haass
Endothelin-1 inhibits the neuronal norepinephrine transporter in hearts of male rats
Cardiovasc Res, August 1, 2005; 67(2): 283 - 290.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. L. Kolo, T. C. Westfall, and H. Macarthur
Modulation of neurotransmitter release by NO is altered in mesenteric arterial bed of spontaneously hypertensive rats
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1842 - H1847.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. L. Kolo, T. C. Westfall, and H. Macarthur
Nitric oxide decreases the biological activity of norepinephrine resulting in altered vascular tone in the rat mesenteric arterial bed
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H296 - H303.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.