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Am J Physiol Heart Circ Physiol (May 23, 2002). doi:10.1152/ajpheart.00187.2002
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Articles in PresS, published online ahead of print May 23, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00187.2002
Submitted on March 6, 2002
Accepted on May 15, 2002

A New Inbred Wistar-Kyoto Rat Substrain Exhibiting Apparent Salt Sensitivity and Borderline Hypertension

Adamu Alemayehu1*, Laura Breen1, and Morton P. Printz1

1 Department of Pharmacology, University of California, La Jolla, CA, USA

* To whom correspondence should be addressed. E-mail: aalemayehu{at}ucsd.edu.

The normotensive Wistar-Kyoto (WKY) rat strain is a traditional control for the spontaneously hypertensive rat (SHR). We found trait differences between two inbred normotensive WKY strains, derived originally from different vendors, and compared these two strains, WKY/lj-tf and WKY/lj-cr, with the inbred SHR/lj-cr for cardiovascular, diurnal and activity traits under normal and high (8%) NaCl diets. Marked genetic diversity was found between the two vendor-derived WKY. Using an extended study design and radiotelemetry we compared WKY/lj-cr, WKY/lj-tf and SHR/lj-cr with the following results: (systolic: 120±1, 133±1, 168±3 mmHg); diurnal variation in heart rate ({Delta})HR; 46±3, 71±4, 57±2 bpm) and salt sensitivity of arterial pressure ({Delta})systolic; 10±1, 21±1, 20±1 mmHg), respectively. The WKY/lj-tf genotype apparently results in compromised control of arterial pressure and heart rate, especially during high NaCl intake, and greater susceptibility to high pressure - high NaCl induced secondary changes. WKY/lj-tf thus constitutes a new inbred borderline hypertensive WKY substrain offering unique opportunities for genomic studies into the development of genetic hypertension.




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