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1 Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States
2 Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States; Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States
3 Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah, United States
4 Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States
* To whom correspondence should be addressed. E-mail: jwagenseil{at}cellbiology.wustl.edu.
Mice heterozygous for the elastin gene (ELN+/-) show unique cardiovascular properties, including increased blood pressure and smaller, thinner arteries with an increased number of lamellar units. Some of these properties are also observed in humans with supravalvular aortic stenosis (SVAS), a disease caused by functional heterozygosity of the elastin gene. The arterial geometry in ELN+/- mice is contrary to the increased thickness that would be expected in an animal demonstrating hypertensive remodeling. To determine if this is due to a decreased capability for cardiovascular remodeling or to a novel adaptation of the ELN+/- cardiovascular system, we increased blood pressure in adult ELN+/+ and +/- mice using the two-kidney, one-clip (2K1C) Goldblatt model of hypertension. Successfully clipped mice have a systolic pressure increase of at least 15 mmHg over sham operated animals. ELN+/+ and +/- clipped mice show significant increases over sham in cardiac weight, arterial thickness and arterial cross-sectional area with no changes in lamellar number. There are no significant differences in most mechanical properties with clipping in either genotype. These results indicate that ELN+/+ and +/- hearts and arteries remodel similarly in response to adult induced hypertension. Therefore, the cardiovascular properties of ELN+/- mice are likely due to developmental remodeling in response to altered hemodynamics and reduced elastin levels.
This article has been cited by other articles:
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  J. E. Wagenseil and R. P. Mecham Vascular Extracellular Matrix and Arterial Mechanics Physiol Rev, July 1, 2009; 89(3): 957 - 989. [Abstract] [Full Text] [PDF]
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 J. E. Wagenseil, C. H. Ciliberto, R. H. Knutsen, M. A. Levy, A. Kovacs, and R. P. Mecham Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice Circ. Res., May 22, 2009; 104(10): 1217 - 1224. [Abstract] [Full Text] [PDF]
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