| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Division of Cardiology, Pennsylvania State University College of Medicine, Hershey, PA, USA
2 Division of Cardiology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Lebanon VA Medical Center, Lebanon, PA, USA
* To whom correspondence should be addressed. E-mail: lsinoway{at}psu.edu.
During exercise the sympathetic nervous system is activated causing vasoconstriction. The autonomic mechanisms responsible for this vasoconstriction vary based on the particular tissue being studied. Attempts to examine reflex control of the human renal circulation have been difficult because of technical limitations. In this report the Doppler technique was used to examine renal flow velocity during four muscle contraction paradigms in conscious humans. Flow velocity was divided by mean arterial blood pressure (MAP) yielding an index of renal vascular resistance (RVR). Fatiguing static handgrip (40% maximal voluntary contraction [MVC]) increased RVR by 76%. During post-handgrip circulatory arrest (PHG-CA), RVR remained above baseline (2.1 ± .2 vs. 2.8 ± .2, P < .017) but was only 40% of endgrip RVR. Voluntary biceps contraction increased RVR within 10 s of initiating contraction. This effect was not associated with an increase in BP. Finally, involuntary biceps contraction also raised RVR. We conclude that muscle contraction evokes renal vasoconstriction in conscious humans. The characteristic of this response is consistent with a primary role for mechanically sensitive afferents. This statement is based on the small PHG-CA response and the vasoconstriction seen with involuntary biceps contraction.
This article has been cited by other articles:
|
|
 |
|
  N. T. Kuipers, C. L. Sauder, M. L. Kearney, and C. A. Ray Interactive effect of aging and local muscle heating on renal vasoconstriction during isometric handgrip Am J Physiol Renal Physiol, August 1, 2009; 297(2): F327 - F332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. McCord, H. Tsuchimochi, and M. P. Kaufman Acid-sensing ion channels contribute to the metaboreceptor component of the exercise pressor reflex Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H443 - H449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Momen, J. Cui, P. McQuillan, and L. I. Sinoway Local prostaglandin blockade attenuates muscle mechanoreflex-mediated renal vasoconstriction during muscle stretch in humans Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2184 - H2190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Y. Endo, R. Suzuki, N. Nagahata, N. Hayashi, A. Miura, S. Koga, and Y. Fukuba Differential arterial blood flow response of splanchnic and renal organs during low-intensity cycling exercise in women Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2322 - H2326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Matsukawa and T. Nakamoto Muscle mechanosensitive reflex is suppressed in the conscious condition: effect of anesthesia J Appl Physiol, January 1, 2008; 104(1): 82 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. T. Kuipers, C. L. Sauder, M. L. Kearney, and C. A. Ray Changes in forearm muscle temperature alter renal vascular responses to isometric handgrip Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3432 - H3439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Kindig, S. G. Hayes, and M. P. Kaufman Blockade of purinergic 2 receptors attenuates the mechanoreceptor component of the exercise pressor reflex Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2995 - H3000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Wilson, C. L. Sauder, M. L. Kearney, N. T. Kuipers, U. A. Leuenberger, K. D. Monahan, and C. A. Ray Skin-surface cooling elicits peripheral and visceral vasoconstriction in humans J Appl Physiol, October 1, 2007; 103(4): 1257 - 1262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Shoemaker, L. Mattar, P. Kerbeci, S. Trotter, P. Arbeille, and R. L. Hughson WISE 2005: stroke volume changes contribute to the pressor response during ischemic handgrip exercise in women J Appl Physiol, July 1, 2007; 103(1): 228 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nakamoto and K. Matsukawa Muscle mechanosensitive receptors close to the myotendinous junction of the Achilles tendon elicit a pressor reflex J Appl Physiol, June 1, 2007; 102(6): 2112 - 2120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Stewart, L. D. Montgomery, J. L. Glover, and M. S. Medow Changes in regional blood volume and blood flow during static handgrip Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H215 - H223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Matsukawa, T. Nakamoto, and A. Inomoto Gadolinium does not blunt the cardiovascular responses at the onset of voluntary static exercise in cats: a predominant role of central command Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H121 - H129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Kaufman Mechanoreceptors and central command Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H117 - H118. [Full Text] [PDF]
|
|
|
|
|
|
A. Momen, B. Handly, A. Kunselman, U. A. Leuenberger, and L. I. Sinoway Influence of sex and active muscle mass on renal vascular responses during static exercise Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H121 - H126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Momen, K. Thomas, C. Blaha, A. Gahremanpour, A. Mansoor, U. A. Leuenberger, and L. I. Sinoway Renal vasoconstrictor responses to static exercise during orthostatic stress in humans: effects of the muscle mechano- and the baroreflexes J. Physiol., June 15, 2006; 573(3): 819 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Koba, T. Yoshida, and N. Hayashi Renal sympathetic and circulatory responses to activation of the exercise pressor reflex in rats Exp Physiol, January 1, 2006; 91(1): 111 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hayashi, N. Someya, M. Y. Endo, A. Miura, and Y. Fukuba Vasoconstriction and blood flow responses in visceral arteries to mental task in humans Exp Physiol, January 1, 2006; 91(1): 215 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Momen, D. Bower, U. A. Leuenberger, J. Boehmer, S. Lerner, E. J. Alfrey, B. Handly, and L. I. Sinoway Renal vascular response to static handgrip exercise: sympathetic vs. autoregulatory control Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1770 - H1776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. I. Sinoway and J. Li A perspective on the muscle reflex: implications for congestive heart failure J Appl Physiol, July 1, 2005; 99(1): 5 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Momen, D. Bower, J. Boehmer, A. R. Kunselman, U. A. Leuenberger, and L. I. Sinoway Renal blood flow in heart failure patients during exercise Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2834 - H2839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, A. N. Sinoway, Z. Gao, M. D. Maile, M. Pu, and L. I. Sinoway Muscle Mechanoreflex and Metaboreflex Responses After Myocardial Infarction in Rats Circulation, November 9, 2004; 110(19): 3049 - 3054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Momen, U. A. Leuenberger, B. Handly, and L. I. Sinoway Effect of aging on renal blood flow velocity during static exercise Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H735 - H740. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
