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Articles in PresS, published online ahead of print May 23, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00216.2002
Submitted on March 14, 2002
Accepted on May 17, 2002
1 Cardiovascular Research Centre, Monash Medical Centre, Monash University, Melbourne, Victoria, Australia
2 La Trobe University, Melbourne, Victoria, Australia
* To whom correspondence should be addressed. E-mail: James.Cameron{at}baker.edu.au.
Arterial transfer functions have been promoted for the derivation of central aortic waveform characteristics not usually accessible non-invasively, but possibly of prognostic significance. The utility of generalized rather than gender-specific transfer functions has not been assessed. Invasive central aortic and non-invasive radial (Millar® Mikro-tip® tonometer) blood pressure waveforms were recorded simultaneously in 78 subjects (61M:17F). Average transfer functions were obtained for the whole group and for each gender by 2 methods. Reverse transformation was performed using each transfer function. Measured aortic waveform parameters were compared with those derived using average, gender appropriate and inappropriate transfer functions. Differences in central waveform characteristics were demonstrated between men and women. Derived waveform parameters were significantly different from measured values (e.g. subendocardial viability index, augmentation index (P<0.001)). A gender appropriate transfer function significantly improved the derivation of some parameters, including systolic pressure, and systolic and diastolic pressure time integrals (P<0.05). Generalized arterial transfer functions may not be universally applicable across all waveform parameters of potential interest and gender-specific transfer functions may be more appropriate.
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