AJP - Heart Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (July 18, 2002). doi:10.1152/ajpheart.00217.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/5/H1887    most recent
00217.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lorita, J.
Right arrow Articles by Ramirez, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lorita, J.
Right arrow Articles by Ramirez, I.

Articles in PresS, published online ahead of print July 18, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00217.2002
Submitted on March 13, 2002
Accepted on July 8, 2002

Effects of epidermal growth factor on adrenaline-stimulated heart function in rodents

Jordi Lorita1, Noelia Escalona1, Susanna Faraudo1, Maria Soley1, and Ignasi Ramirez1*

1 Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain

* To whom correspondence should be addressed. E-mail: sunyer{at}bio.ub.es.

Epidermal Growth Factor (EGF) interferes with ß-adrenergic receptor (ßAR) signaling in adipocytes and hepatocytes, which leads to decreased lipolytic and glycogenolytic responses, respectively. We studied the effect of EGF on the heart. EGF interfered with the cyclic AMP signal generated by ßAR agonists in cardiac myocytes. In perfused hearts, EGF decreased inotropic and chronotropic responses to adrenaline but not to (chlorophenylthio)-cyclic-AMP. Sustained adrenaline infusion induced heart contracture, which resulted in altered heart function: decreased inotropy and increased heart rate variability. EGF prevented all these alterations. In the whole animal (anesthetized mice), EGF administration reduced the rise in heart rate induced by a single adrenaline dose and the occurrence of Bezold-Jarisch reflex episodes induced by repeated doses. Sialoadenectomy enhanced the response to adrenaline, and EGF administration restored normal response. All these results suggest that, by interfering with ß signaling, EGF protects the heart against the harmful effects of adrenaline.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. Rajagopalan, I. H. Zucker, J. A. Jones, M. Carlson, and Y. J. Ma
Cardiac ErbB-1/ErbB-2 mutant expression in young adult mice leads to cardiac dysfunction
Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H543 - H554.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Pareja, O. Sanchez, J. Lorita, M. Soley, and I. Ramirez
Activated epidermal growth factor receptor (ErbB1) protects the heart against stress-induced injury in mice
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R455 - R462.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.