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Am J Physiol Heart Circ Physiol (June 5, 2003). doi:10.1152/ajpheart.00217.2003
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Submitted on March 10, 2003
Accepted on June 3, 2003

Elevated Plasma Levels of Human Urotensin-II Immunoreactivity in Congestive Heart Failure

Fraser D Russell1*, Deborah Meyers2, Andrew J Galbraith2, Nick Bett2, Istvan Toth3, Philip Kearns3, and Peter Molenaar1

1 Department of Medicine, University of Queensland, Chermside, Queensland, Australia
2 Department of Cardiology, The Prince Charles Hospital, Chermside, Queensland, Australia
3 School of Pharmacy, University of Queensland, St. Lucia, Queensland, Australia

* To whom correspondence should be addressed. E-mail: russell{at}medicine.uq.edu.au.

Human urotensin-II (hU-II) is the most potent endogenous cardiostimulant identified to date. We therefore determined whether hU-II has a possible pathological role by investigating its'levels in patients with congestive heart failure (CHF). Blood samples were obtained from the aortic root, femoral artery, femoral vein and pulmonary artery from patients with CHF undergoing cardiac catheterization, and the aortic root from patients who were undergoing investigative angiography for chest pain, but were not in heart failure. Immunoreactive hU-II levels (hU-II-ir) were determined using radioimmunoassay. hU-II-ir was elevated in the aortic root of patients with CHF (230.9±68.7 pg/ml, n=21; P<0.001) compared to patients with non-failing hearts (22.7±6.1 pg/ml, n=18). This increase was attributed to cardiopulmonary production of hU-II-ir since levels were lower in the pulmonary artery (38.2±6.1 pg/ml, n=21; P<0.001) than in the aortic root (above). hU-II-ir levels were elevated in the aortic root of CHF patients with non-ischemic cardiomyopathy (142.1±51.5 pg/ml, n=10; P<0.05) compared to patients with non-failing hearts without coronary artery disease (27.3±12.4 pg/ml, n=7), and CHF patients with ischemic cardiomyopathy (311.6±120.4 pg/ml, n=11; P<0.001) compared to patients with non-failing hearts with coronary artery disease (19.8±6.6 pg/ml, n=11). hU-II-ir levels were significantly higher in the aortic root than in the pulmonary artery and femoral vein, with a non-significant trend for higher levels in the aortic root than in the femoral artery. The findings indicated that hU-II-ir levels are elevated in the aortic root of patients with CHF and that hU-II-ir is cleared at least in part from the microcirculation.




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