| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print July 18, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00223.2002
Submitted on March 13, 2002
Accepted on July 14, 2002
1 Experimental Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands; Physiology, Medical College of Wisconsin, Milwaukee, WI, USA
2 Experimental Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
* To whom correspondence should be addressed. E-mail: merkus{at}tch.fgg.eur.nl.
Coronary tone is determined by a balance between endogenously produced endothelin and metabolic dilators. We hypothesized that coronary vasodilation during augmented metabolism is the net result of decreased endothelin-production and increased production of vasodilators. Isolated rat myocytes were stimulated at 0,200 and 400 bpm to modify metabolism. Supernatant from these preparations was added to isolated coronary arterioles with and without blocking vasoactive pathways (adenosine, bradykinin and endothelin). Chronically instrumented swine were studied while resting and running on a treadmill before and after endothelin A-receptor (ETA) blockade. Vasodilatory properties of the supernatant increased with increased stimulation frequencies. Combined blockade of adenosine and bradykinin receptors abolished vasodilation in response to supernatant of stimulated myocytes. ETA-blockade increased vasodilation to supernatant of unstimulated myocytes but did not affect dilation to supernatant of myocytes stimulated at 400 bpm. In vivo, ETA-blockade resulted in coronary vasodilation at rest, which waned during exercise. Thus, ET has a tonic constrictor influence through the ETA receptor at low myocardial metabolic demand, but its influence decreased during increased metabolism.
This article has been cited by other articles:
|
|
 |
|
  O. Yamaguchi, T. Kaneshiro, S.-i. Saitoh, T. Ishibashi, Y. Maruyama, and Y. Takeishi Regulation of coronary vascular tone via redox modulation in the {alpha}1-adrenergic-angiotensin-endothelin axis of the myocardium Am J Physiol Heart Circ Physiol, January 1, 2009; 296(1): H226 - H232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Spaan, C. Kolyva, J. van den Wijngaard, R. ter Wee, P. van Horssen, J. Piek, and M. Siebes Coronary structure and perfusion in health and disease Phil Trans R Soc A, September 13, 2008; 366(1878): 3137 - 3153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Duncker and R. J. Bache Regulation of Coronary Blood Flow During Exercise Physiol Rev, July 1, 2008; 88(3): 1009 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J. de Beer, O. Sorop, D. A. Pijnappels, D. H. Dekkers, F. Boomsma, J. M. J. Lamers, D. J. Duncker, and D. Merkus Integrative control of coronary resistance vessel tone by endothelin and angiotensin II is altered in swine with a recent myocardial infarction Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2069 - H2077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Saitoh, T. Kiyooka, P. Rocic, P. A. Rogers, C. Zhang, A. Swafford, G. M. Dick, C. Viswanathan, Y. Park, and W. M. Chilian Redox-dependent coronary metabolic dilation Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3720 - H3725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Duncker and D. Merkus Exercise hyperaemia in the heart: the search for the dilator mechanism J. Physiol., September 15, 2007; 583(3): 847 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-i. Saitoh, C. Zhang, J. D. Tune, B. Potter, T. Kiyooka, P. A. Rogers, J. D. Knudson, G. M. Dick, A. Swafford, and W. M. Chilian Hydrogen Peroxide: A Feed-Forward Dilator That Couples Myocardial Metabolism to Coronary Blood Flow Arterioscler Thromb Vasc Biol, December 1, 2006; 26(12): 2614 - 2621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Merkus, O. Sorop, B. Houweling, B. A. Hoogteijling, and D. J. Duncker KCa+ channels contribute to exercise-induced coronary vasodilation in swine Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2090 - H2097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Merkus, O. Sorop, B. Houweling, F. Boomsma, A. H. van den Meiracker, and D. J. Duncker NO and prostanoids blunt endothelin-mediated coronary vasoconstrictor influence in exercising swine Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2075 - H2081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Merkus, D. B. Haitsma, O. Sorop, F. Boomsma, V. J. de Beer, J. M. J. Lamers, P. D. Verdouw, and D. J. Duncker Coronary vasoconstrictor influence of angiotensin II is reduced in remodeled myocardium after myocardial infarction Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2082 - H2089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Tune Withdrawal of vasoconstrictor influences in local metabolic coronary vasodilation Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2044 - H2046. [Full Text] [PDF]
|
|
|
|
|
|
N. Westerhof, C. Boer, R. R. Lamberts, and P. Sipkema Cross-talk between cardiac muscle and coronary vasculature. Physiol Rev, October 1, 2006; 86(4): 1263 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Brzezinska, D. Merkus, and W. M. Chilian Metabolic communication from cardiac myocytes to vascular endothelial cells Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2232 - H2237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Shipley and J. M. Muller-Delp Aging decreases vasoconstrictor responses of coronary resistance arterioles through endothelium-dependent mechanisms Cardiovasc Res, May 1, 2005; 66(2): 374 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Merkus, A. K. Brzezinska, C. Zhang, S. Saito, and W. M. Chilian Cardiac myocytes control release of endothelin-1 in coronary vasculature Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2088 - H2092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Gorman, M. Farias III, K. N. Richmond, J. D. Tune, and E. O. Feigl Role of endothelin in {alpha}-adrenoceptor coronary vasoconstriction Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1937 - H1942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Merkus, B. Houweling, A. H. van den Meiracker, F. Boomsma, and D. J. Duncker Contribution of endothelin to coronary vasomotor tone is abolished after myocardial infarction Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H871 - H880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Okajima, R. Parent, E. Thorin, and M. Lavallee Pathophysiological plasma ET-1 levels antagonize {beta}-adrenergic dilation of coronary resistance vessels in conscious dogs Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1476 - H1483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. C. Alders, A. B. J. Groeneveld, F. J. J. de Kanter, and J. H. G. M. van Beek Myocardial O2 consumption in porcine left ventricle is heterogeneously distributed in parallel to heterogeneous O2 delivery Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1353 - H1361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Tune, M. W. Gorman, and E. O. Feigl Matching coronary blood flow to myocardial oxygen consumption J Appl Physiol, July 1, 2004; 97(1): 404 - 415. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
