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Articles in PresS, published online ahead of print July 26, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00224.2002
Submitted on March 18, 2002
Accepted on July 15, 2002
1 Biomedical Engineering, University of California, Irvine, Irvine, CA, USA
2 Radiology, University of California, San Diego, San Diego, CA, USA
* To whom correspondence should be addressed. E-mail: gkassab{at}uci.edu.
The goal of the present study is to obtain a systematic set of data along the length of the mouse aorta to study variation of morphometry (diameter, wall thickness and curvature), strain and stress of the mouse aorta. Five mice were imaged with a 13 MHz ultrasound probe to determine the in vivo diameter along the aorta. A cast was made of these aortas to validate the ultrasonic diameter measurements. The root mean squared and systematic errors for these measurements were 12.6% and 6.4% of the mean ultrasound diameter, respectively. The longitudinal variation of geometry, stress and strain from the aortic valve to the common iliac bifurcation was documented. Our results show that the residual circumferential strain leads to a uniformity of transmural strain of the aorta in the loaded state along the entire length of the aorta. Furthermore, we validated the incompressibility condition along the length of the aorta. These data of normal mice will serve as a reference state for the study of disease in future knockout models.
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