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Articles in PresS, published online ahead of print April 18, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00238.2002
Submitted on March 20, 2002
Accepted on April 14, 2002
1 Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
* To whom correspondence should be addressed. E-mail: jmcneill{at}interchange.ubc.ca.
Hyperinsulinemia and insulin resistance have been linked to hypertension, however, the influence of sex on this relationship has not been well studied. The purpose of this experiment was to compare the effects of chronic insulin treatment on insulin sensitivity and blood pressure in male and female rats. Male and female Wistar rats were treated with insulin (2 U / d) via subcutaneous sustained release implants for 5 weeks. Systolic blood pressure was measured via the tail cuff method before and after treatment and insulin sensitivity was assessed with an oral glucose tolerance test. The insulin sensitivity of female rats was 4.5 fold greater than males. Chronic insulin treatment impaired insulin sensitivity in both sexes, however, this occurred to a greater degree in males. Blood pressure increased in males treated with insulin only. The results demonstrate that hyperinsulinemia and insulin resistance are associated with hypertension in male rats only. Therefore, the link between these conditions appears to depend on sex.
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