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Am J Physiol Heart Circ Physiol (June 27, 2002). doi:10.1152/ajpheart.00245.2002
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Articles in PresS, published online ahead of print June 27, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00245.2002
Submitted on March 20, 2002
Accepted on June 19, 2002

Role of oxidative phosphorylation and ATP release in mediating birth related pulmonary vasodilation in fetal lambs

Girija G. Konduri1* and Janine Mattei2

1 Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
2 Pediatrics, Wayne State UNiversity, Detroit, MI, USA

* To whom correspondence should be addressed. E-mail: gkonduri{at}mcw.edu.

We investigated the hypothesis that birth-related pulmonary vasodilation is mediated in part by an increase in oxidative phosphorylation and ATP release in response to oxygen exposure at birth. Studies were done in fetal lambs to evaluate the independent effects of oxygen, lung distension alone or accompanied by oxygenation and shear stress on fetal pulmonary blood flow and resistance and plasma ATP levels in pulmonary artery. The effect of each intervention was evaluated in lambs assigned to three groups - control, pretreatment with 2,4-dinitrophenol, or antimycin-A, inhibitors of oxidative phosphorylation. Exposure to oxygen alone or with lung distension was associated with increases in plasma ATP levels and pulmonary blood flow and decrease in pulmonary vascular resistance. Plasma ATP levels did not change during lung distension alone. Dinitrophenol and antimycin-A attenuated the pulmonary vasodilator response to oxygen but did not attenuate the response to lung distension alone. An increase in oxidative phosphorylation and ATP release during oxygen exposure may contribute to birth related pulmonary vasodilation in fetal lambs.




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