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Am J Physiol Heart Circ Physiol (September 5, 2002). doi:10.1152/ajpheart.00250.2002
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Articles in PresS, published online ahead of print September 5, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00250.2002
Submitted on March 20, 2002
Accepted on July 10, 2002

DL-3-hydroxybutyrate Administration Prevents Myocardial Damage Following Coronary Occlusion in Rat Hearts

Zhitian Zou, Shiro Sasaguri*, Rajesh G. Katare, and Ryoko Suzuki

* To whom correspondence should be addressed. E-mail: sasaguri{at}kochi-ms.ac.jp.

To investigate the role of high-concentrations of DL-3-hydroxybutyrate (DL-3-HB) in preventing heart damage after prolonged fasting, infarct size and the incidence of apoptosis caused by ischemia-reperfusion were determined in four groups of Wistar rats. Fed rats (±DL-3-HB group) and fasted rats (±DL-3-HB group) were subjected to 30 min of left coronary artery occlusion and 120 min of reperfusion. DL-3-HB was administered intravenously 60 min before the coronary artery occlusion. Infarct size, defined by triphenylyetrazolium chloride (TTC) staining, was reduced from 72±3% (fed group), 75±5% (fed+DL-3-HB group) and 70±5% (fasting group) to 26±4% (P<0.01 vs. fasting+DL-3-HB group). Apoptosis as defined by single-stranded DNA staining was significantly reduced in the subendocardial region in the fasting+DL-3-HB group (9±2%) when compared to the other groups (39±6% in the fed group, 37±5% in the fed+DL-3-HB group and 34±3% in the fasting group, P<0.01). In addition, levels of ATP in the fasting+DL-3-HB group were significantly higher compared to other groups following 30 min of ischemia and 120 min of reperfusion (P<0.01). In conclusion, the present study demonstrates that high-concentrations of DL-3-HB reduces myocardial infarction size and apoptosis induced by ischemia-reperfusion, possibly by providing increased energy substrate to the fasted rat myocardium.




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