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Am J Physiol Heart Circ Physiol (February 10, 2006). doi:10.1152/ajpheart.00269.2005
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Submitted on March 18, 2005
Accepted on January 30, 2006

Left ventricular hypertrophy in mice with a cardiac-specific overexpression of interleukin-1

Kenichiro Nishikawa1, Mikoto Yoshida1, Masatoshi Kusuhara1, Norio Ishigami1, Kikuo Isoda1, Kohji Miyazaki1, and Fumitaka Ohsuzu1*

1 Internal Medicine-1, National Defense Medical College, 3-2 Namiki Tokorozawa, Saitama, Japan

* To whom correspondence should be addressed. E-mail: ohsuzu{at}ndmc.ac.jp.

Background:Recent studies have identified the importance of proinflammatory cytokines in the development of left ventricular (LV) hypertrophy. However, the precise role of interleukin-1 (IL-1), one of the major proinflammatory cytokines, in the myocardium, is still not fully understood. In this study, we investigated the pathophysiological consequences of the cardiac expression of IL-1 in-vivo. Methods and Results:We generated mice with a cardiac-specific overexpression of human IL-1{alpha}. We then analyzed their heart morphology and functions. Both histological and echocardiographic analyses revealed concentric LV hypertrophy with a preserved LV systolic function in the mice. Conclusions:Our results suggest that the myocardial expression of IL-1 is sufficient to cause LV hypertrophy.




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