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Am J Physiol Heart Circ Physiol (August 29, 2002). doi:10.1152/ajpheart.00282.2002
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Articles in PresS, published online ahead of print August 29, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00282.2002
Submitted on April 2, 2002
Accepted on August 5, 2002

Functional and metabolic adaptation of the heart to prolonged thyroid hormone treatment

Hans Degens1, Andries J Gilde1, Martijn Lindhout1, Peter H Willemsen1, Ger J Van der Vusse1, and Marc Van Bilsen1*

1 Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

* To whom correspondence should be addressed. E-mail: marc.vanbilsen{at}fys.unimaas.nl.

In heart failure thyroid hormone (TH) treatment improves cardiac performance. Long-term effects of TH on cardiac function and metabolism, however, are incompletely known. To investigate the effects of up to 28 days TH treatment, male Wistar rats daily received T3 (200 µg*kg-1 sc) leading to a 2.5-fold rise in plasma fatty acids (FA) level and progressive cardiac hypertrophy (+47% after 28 days) (p < 0.001). Ejection fraction (echocardiography) was increased (+12%; p < 0.05) between 7 and 14 days and declined thereafter. Neither cardiac FA oxidation and glycolytic capacity (homogenates) per unit muscle mass, nor mRNA levels of proteins involved in FA and glucose uptake and metabolism (Northern blots and micro-array) were altered. After 28 days of treatment mRNA levels of uncoupling proteins 2/3 (UCP2/3) and atrial natriuretic factor (ANF) were increased (p < 0.05). This indicates that TH-induced hypertrophy is associated with an initial increase in cardiac performance, followed by a decline in cardiac function and increased expression of UCP's and ANF, suggesting that detrimental effects eventually prevail.




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