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1 Pediatrics, Division of Pediatric Cardiology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Zuid-holland, Netherlands
2 Cardiology, Leiden University Medical Center, Leiden, Netherlands
3 Epidemiology and Biostatistics, Erasmus MC, Rotterdam, Zuid-holland, Netherlands
4 Clinical Pharmacology/Cardiology, University Medical Center Groningen, Goningen, groningen, Netherlands
5 Experimental Cardiology, Erasmus MC, Rotterdam, Netherlands
6 Biochemistry, Erasmus MC, Rotterdam, Netherlands
* To whom correspondence should be addressed. E-mail: m.dalinghaus{at}erasmusmc.nl.
In many patients with congenital heart disease, the right ventricle (RV) is subjected to abnormal loading conditions. In order to better understand the state of compensated RV hypertrophy, which could eventually progress to decompensation, we studied the effects of RV pressure overload in rats. In the present study we report the biventricular adaptation to 6 weeks of pulmonary artery banding (PAB). PAB resulted in a RV pressure overload to approximately 60% of systemic level and a 2-fold increase in RV mass (p<0.01). Systemic hemodynamic parameters were not altered and overt signs of heart failure were absent. Load-independent measures of ventricular function (ESPVR, PRSW, dP/dtMax-Ved), assessed by means of pressure-volume (PV) loops, demonstrated an 2-3 fold increase in RV contractility under baseline conditions in PAB rats. RV contractility increased in response to dobutamine stimulation (2.5 µg/kg/min) both in PAB as in sham operated rats in a similar fashion, indicating preserved RV contractile reserve in PAB rats. Left ventricular (LV) contractility at baseline was unaffected in PAB rats, although LV volume in PAB rats was slightly decreased. LV contractility increased in response to dobutamine (2.5 µg/kg/min) both in PAB and sham rats, while the response to a higher dose of dobutamine (5 µg/kg/min) was blunted in PAB rats. Six weeks of RV pressure overload in rats resulted in a state of compensated RV hypertrophy with preserved RV contractile reserve, while LV contractile state at baseline was not affected. Furthermore, this study demonstrates the feasibility of performing biventricular PV-loop measurements in rats.
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