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Am J Physiol Heart Circ Physiol (August 22, 2002). doi:10.1152/ajpheart.00298.2002
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Articles in PresS, published online ahead of print August 22, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00298.2002
Submitted on April 4, 2002
Accepted on July 23, 2002

Effects of Longitudinal Stretch on VSM Tone and Distensibility of Muscular Conduit Arteries

Martin A Zulliger1*, Naomi T Kwak1, Theodora Tsapikouni1, and Nikos Stergiopulos1

1 Laboratory of Hemodynamics and Cardiovascular Technology, Swiss Federal Institute of Techology (EPFL), Lausanne, VD, Switzerland

* To whom correspondence should be addressed. E-mail: martin.zulliger{at}epfl.ch.

With progressing age large arteries diminish their longitudinal stretch, which in extreme cases results in tortuosity. Increased age is also associated with loss of vessel distensibility. We measured pressure-diameter curves from muscular porcine carotid arteries ex vivo at different longitudinal stretch ratios ({lambda}z=1.4 and 1.8) and under different VSM conditions (fully relaxed, normal VSM tone, and maximally contracted). Distensibility was found to be halved by decreasing longitudinal stretch form {lambda}z=1.8 to {lambda}z=1.4 at physiological pressures. This counterintuitive observation is possible because of the artery's highly non-linear elastic modulus and anisotropic properties. Further, a significantly larger basal VSM contraction was observed at {lambda}z=1.8 than at {lambda}z=1.4, although this was clearly not related to a myogenic response during inflation. This dependence of VSM tone to longitudinal stretch may have possible implications on the functional characteristics of the arterial wall.




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