AJP - Heart BIOPAC complete lab solutions
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (July 22, 2005). doi:10.1152/ajpheart.00306.2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
289/6/H2733    most recent
00306.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Protsenko, Y. L
Right arrow Articles by Markhasin, V. S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Protsenko, Y. L
Right arrow Articles by Markhasin, V. S
Submitted on March 29, 2005
Accepted on July 15, 2005

Hybrid duplex - a novel method to study the contractile function of heterogeneous myocardium

Yuri L Protsenko1*, Sergey M Routkevitch1, Vyacheslav Y Gur'ev2, Leonid B Katsnelson1, Olga Solovyova2, Oleg N Lookin1, Alexander A Balakin1, Peter Kohl3, and Vladimir S Markhasin1

1 Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
2 Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation; Ural State University, Ekaterinburg, Russian Federation
3 University Laboratory of Physiology, Oxford, United Kingdom

* To whom correspondence should be addressed. E-mail: ylp{at}efif.uran.ru.

A new experimental approach is described in detail. The effects of mechanical interaction between different regions of the ventricular wall were earlier experimentally mimicked by us via allowing pairs of independently maintained cardiac muscle fibers to interact mechanically, either in series or in parallel. This simple physiological model of heterogeneous myocardium has been termed "duplex", and has provided new insight into basic effects of cardiac electro-mechanical heterogeneity. Here, we present a novel "hybrid duplex", where one of the elements is an isolated cardiac muscle, and the other - a "virtual cardiac muscle". The virtual muscle is represented by a computational model of cardiomyocyte electro-mechanical activity. We present in detail the computer-based digital control system that governs the mechanical interaction between virtual and biological muscle, the software used for data analysis, and working implementations of the model. Advantages of the hybrid duplex method are discussed, and experimental recordings are presented for illustration and as proof-of-principle.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Iribe, M. Helmes, and P. Kohl
Force-length relations in isolated intact cardiomyocytes subjected to dynamic changes in mechanical load
Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1487 - H1497.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc AHome page
O Solovyova, L.B Katsnelson, P Konovalov, O Lookin, A.S Moskvin, Yu.L Protsenko, N Vikulova, P Kohl, and V.S Markhasin
Activation sequence as a key factor in spatio-temporal optimization of myocardial function
Phil Trans R Soc A, June 15, 2006; 364(1843): 1367 - 1383.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1977 by the American Physiological Society.